Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development
Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development
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Foxc1 在颅骨发育过程中整合 Fgf 和 Bmp 信号，独立于扭曲或 noggin
DOI：
10.1002/dvdy.20430
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发表时间：
2005
影响因子：
2.5
通讯作者：
I. Thesleff
中科院分区：
文献类型：
--
作者：
R. Rice;D. Rice;I. Thesleff
颅骨和骨缝发育受到复杂的调控，其中骨形态发生蛋白（Bmp）和成纤维细胞生长因子（Fgf）信号传导与Msx 2/Twist和Noggin相互作用，分别调控额骨原基增殖和骨缝融合。我们以前已经表明，翼螺旋转录因子Foxc 1，这是必要的颅骨发育，是必需的BMP调节Msx 2。我们现在表明，FGF 2调节Foxc 1的表达，这表明Foxc 1整合了Bmp和Fgf信号通路。我们还表明，Foxc 1是不需要收购成骨潜能或成骨细胞的分化。Fgf受体和Twist的表达在Foxc 1缺陷的颅骨间充质中是正常的，并且异位FGF 2能够诱导骨桥蛋白的表达。此外，我们证明Foxc 1不参与Noggin表达的调节。我们的研究结果表明，Foxc 1整合BMP和Fgf信号通路独立的扭曲或头蛋白。这个信号网络对于颅骨的正确模式和生长至关重要。发展动力学233：847-852，2005年。© 2005 Wiley利斯公司
Calvarial bone and suture development is under complex regulation where bone morphogenetic protein (Bmp) and fibroblast growth factor (Fgf) signalling interact with Msx2/Twist and Noggin and regulate frontal bone primordia proliferation and suture fusion, respectively. We have shown previously that the winged helix transcription factor Foxc1, which is necessary for calvarial bone development, is required for the Bmp regulation of Msx2. We now show that FGF2 regulates the expression of Foxc1, indicating that Foxc1 integrates Bmp and Fgf signalling pathways. We also show that Foxc1 is not needed for the acquisition of osteogenic potential or for the differentiation of osteoblasts. The expression of Fgf receptors and Twist were normal in Foxc1‐deficient calvarial mesenchyme, and ectopic FGF2 was able to induce the expression Osteopontin. Furthermore, we demonstrate that Foxc1 does not participate in the regulation of Noggin expression. Our findings indicate that Foxc1 integrates the Bmp and Fgf signalling pathways independently of Twist or Noggin. This signalling network is essential for the correct patterning and growth of calvarial bones. Developmental Dynamics 233:847–852, 2005. © 2005 Wiley‐Liss, Inc.
影响因子：
4.6
作者：
Hyun-Jung Kim;D. Rice;P. Kettunen;I. Thesleff
通讯作者：
Hyun-Jung Kim;D. Rice;P. Kettunen;I. Thesleff
影响因子：
3.5
作者：
Hong, HK;Lass, JH;Chakravarti, A
通讯作者：
Chakravarti, A