Lifetime Fruit and Vegetable Consumption and Arterial Pulse Wave Velocity in Adulthood The Cardiovascular Risk in Young Finns Study
Lifetime Fruit and Vegetable Consumption and Arterial Pulse Wave Velocity in Adulthood The Cardiovascular Risk in Young Finns Study
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DOI：
10.1161/circulationaha.110.969279
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发表时间：
2010-12-14
期刊：
影响因子：
37.8
通讯作者：
Kahonen, Mika
中科院分区：
文献类型：
--
作者：
Aatola, Heikki;Koivistoinen, Teemu;Kahonen, Mika
儿童期生活方式危险因素与成年期脉搏波传导速度（PWV）之间的关系尚未报道。我们研究了儿童和成年生活方式的危险因素是否与PWV评估adultary.Methods和Results-The研究队列包括1622名受试者的心血管风险在年轻的芬兰人研究随访27年以来的基线（1980年，年龄3至18岁）与生活方式的危险因素的数据，因为童年。于2007年用全身阻抗心动图仪测量动脉PWV。儿童期蔬菜摄入量与成年期PWV呈负相关（β =-0.06，P=0.02），当调整传统危险因素（高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、收缩压、体重指数和吸烟）后，这种相关性仍然显著（β =-0.07，P=0.004）。当调整生活方式或传统危险因素时，蔬菜消费也是成年PWV的独立预测因子（分别为β =-0.08，P=0.002和β =-0.07，P=0.0007）。从儿童期到成年期，水果和蔬菜的持续高消费与持续低消费相比，PWV较低（两者P=0.03）。儿童期生活方式危险因素（蔬菜消费、水果消费、体力活动和吸烟的最低五分位数）的数量与成年期PWV直接相关（P=0.001）。这种关联仍然显着调整后的生活方式的危险因素在成年期（P=0.003）。结论这些研究结果表明，终生的生活方式的危险因素，特别是水果和蔬菜的低消费，与动脉硬化在年轻的成年人。（循环。2010;122：2521-2528）。
Background-The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood.Methods and Results-The study cohort comprised 1622 subjects of the Cardiovascular Risk in Young Finns Study followed up for 27 years since baseline (1980; aged 3 to 18 years) with lifestyle risk factor data available since childhood. Arterial PWV was measured in 2007 by whole-body impedance cardiography device. Vegetable consumption in childhood was inversely associated with adulthood PWV (beta=-0.06, P=0.02), and this association remained significant (beta=-0.07, P=0.004) when adjusted for traditional risk factors (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure, body mass index, and smoking). Vegetable consumption was also an independent predictor of PWV in adulthood when adjusted for lifestyle or traditional risk factors (beta=-0.08, P=0.002 and beta=-0.07, P=0.0007, respectively). Persistently high consumption of both fruits and vegetables from childhood to adulthood was associated with lower PWV compared with persistently low consumption (P=0.03 for both). The number of lifestyle risk factors (the lowest quintile for vegetable consumption, fruit consumption, physical activity, and smoking) in childhood was directly associated with PWV in adulthood (P=0.001). This association remained significant when adjusted for the number of lifestyle risk factors in adulthood (P=0.003).Conclusions-These findings suggest that lifetime lifestyle risk factors, with low consumption of fruits and vegetables in particular, are related to arterial stiffness in young adulthood. (Circulation. 2010;122:2521-2528.)