AD brain pathology: Vascular origins? Results from the HAAS autopsy study
AD brain pathology: Vascular origins? Results from the HAAS autopsy study
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DOI：
10.1016/j.neurobiolaging.2007.03.008
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发表时间：
2008-10-01
影响因子：
4.2
通讯作者：
White, Lon R.
中科院分区：
文献类型：
--
作者：
Launer, Lenore J.;Petrovitch, Helen;White, Lon R.
越来越多的研究表明血管与阿尔茨海默病 (AD) 有关。这些发现提出的一个主要问题是血管疾病是否会促进 AD 样病变的形成，或者血管疾病是否只会增加临床严重程度。我们在基于檀香山亚洲老龄化研究的完全表征的尸检样本中研究了这个问题。我们发现，与没有病变的患者相比，神经变性的 AD 标志物（淀粉样蛋白斑、脑淀粉样血管病和神经原纤维缠结）在有神经病理学明确的血管病变的患者中并不常见。我们的研究表明，血管性病变和 AD 型病变的负担是相互独立的，并且与两类病变对认知障碍的累加效应一致。 (C) 2007 Elsevier Inc. 保留所有权利。
An increasing number of studies suggest a vascular contribution to Alzheimer's disease (AD). One major question these findings raise is whether vascular disease enhances the formation of AD-like lesions, or whether vascular disease just adds to clinical severity. We examined this question in a fully characterized autopsy sample based oil the Honolulu Asia Aging Study. We found that AD markers of neurodegeneration (amyloid plaques, cerebral amyloid angiopathy and neurofibrillary tangles) were no more prevalent in those with neuropathologically defined vascular lesions compared to those without lesions. Our study suggests the burden of vascular and AD type lesions are independent of each other, and are consistent with an additive effect of the two types of lesions oil cognitive impairment. (C) 2007 Elsevier Inc. All rights reserved.