Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells.
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DOI：
10.1084/jem.20101159
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发表时间：
2011-09-26
期刊：
影响因子：
--
通讯作者：
Gajewski TF
中科院分区：
文献类型：
--
作者：
Fuertes MB;Kacha AK;Kline J;Woo SR;Kranz DM;Murphy KM;Gajewski TF
抗肿瘤CD8 + T细胞反应的产生需要宿主抗原呈递细胞对I型干扰素有反应性
尽管在许多模型中肿瘤未得到控制，但针对生长的肿瘤，自发性T细胞启动经常发生。然而，促进天然抗肿瘤T细胞反应的先天免疫机制尚未明确。在人类转移性黑色素瘤中，转移性肿瘤组织中的I型干扰素（IFN）转录谱与T细胞标志物之间存在相关性。在小鼠中，肿瘤植入后CD11c +细胞会产生IFN -β，在缺乏IFN -α/βR或Stat1的小鼠中，肿瘤诱导的T细胞启动存在缺陷。在造血细胞区室中，宿主抗原呈递细胞水平需要干扰素信号传导，并且对于CD8α +树突状细胞在肿瘤内的积累是必需的，使用Batf3 - / -小鼠证明了这一点。因此，宿主I型干扰素通过对CD8α +树突状细胞的信号传导，对于生长肿瘤的先天免疫识别至关重要。
The generation of antitumor CD8+ T cell responses requires type I interferon responsiveness in host antigen-presenting cells Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently in response to a growing tumor. However, the innate immune mechanisms that promote natural antitumor T cell responses are undefined. In human metastatic melanoma, there was a correlation between a type I interferon (IFN) transcriptional profile and T cell markers in metastatic tumor tissue. In mice, IFN-β was produced by CD11c+ cells after tumor implantation, and tumor-induced T cell priming was defective in mice lacking IFN-α/βR or Stat1. IFN signaling was required in the hematopoietic compartment at the level of host antigen-presenting cells, and selectively for intratumoral accumulation of CD8α+ dendritic cells, which were demonstrated to be essential using Batf3−/− mice. Thus, host type I IFNs are critical for the innate immune recognition of a growing tumor through signaling on CD8α+ DCs.
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影响因子：
11.2
作者：
Harlin H;Meng Y;Peterson AC;Zha Y;Tretiakova M;Slingluff C;McKee M;Gajewski TF
通讯作者：
Gajewski TF
影响因子：
32.4
作者：
Jung, S;Unutmaz, D;Lang, RA
通讯作者：
Lang, RA
影响因子：
30.5
作者：
Dunn, GP;Bruce, AT;Schreiber, RD
通讯作者：
Schreiber, RD
影响因子：
2.3
作者：
Fortunato, Giuliana;Calcagno, Giuseppe;Sacchetti, Lucia
通讯作者：
Sacchetti, Lucia
影响因子：
11.5
作者：
Kline, Justin;Brown, Ian E.;Gajewski, Thomas F.
通讯作者：
Gajewski, Thomas F.