Towards in vivo Dosimetry for Prostate Radiotherapy with a Transperineal Ultrasound Array: A Simulation Study.
Towards in vivo Dosimetry for Prostate Radiotherapy with a Transperineal Ultrasound Array: A Simulation Study.
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DOI：
10.1109/trpms.2020.3015109
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发表时间：
2021-05
影响因子：
4.4
通讯作者：
Xiang L
中科院分区：
文献类型：
--
作者：
Wang M;Samant P;Wang S;Merill J;Chen Y;Ahmad S;Li D;Xiang L
X射线诱导声计算机断层扫描（XACT）是一种很有前途的成像模式，以监测辐射束的位置和沉积剂量在外部束放射治疗输送。本研究的目的是探讨使用经会阴超声换能器阵列进行XACT成像以指导前列腺放射治疗的可行性。在5 cm×5 cm的平面上设计了一个具有10000个（100×100）超声传感器的定制二维（2D）矩阵超声换能器阵列，其中心频率为1 MHz，以优化三维（3D）体积成像。获得了接受调强放射治疗（IMRT）的前列腺患者的CT扫描和剂量治疗计划。开发了内部模拟来对经会阴超声阵列检测到的时变X射线诱导声学（XA）信号进行建模。3D滤波反投影（FBP）算法已用于3D XACT图像重建。本研究的结果将大大提高放射治疗期间XACT成像用于真实的体内剂量测定的潜力。
X-ray-induced acoustic computed tomography (XACT) is a promising imaging modality to monitor the position of the radiation beam and the deposited dose during external beam radiotherapy delivery. The purpose of this study was to investigate the feasibility of using a transperineal ultrasound transducer array for XACT imaging to guide the prostate radiotherapy. A customized two-dimensional (2D) matrix ultrasound transducer array with 10000 (100×100 elements) ultrasonic sensors with a central frequency of 1 MHz was designed on a 5 cm×5 cm plane to optimize three-dimensional (3D) volumetric imaging. The CT scan and dose treatment plan for a prostate patient undergoing intensity modulated radiation therapy (IMRT) were obtained. In-house simulation was developed to model the time varying X-ray induced acoustic (XA) signals detected by the transperineal ultrasound array. A 3D filtered back projection (FBP) algorithm has been used for 3D XACT image reconstruction. Results of this study will greatly enhance the potential of XACT imaging for real time in vivo dosimetry during radiotherapy.