Formation of dendritic spines with GABAergic synapses by whisker stimulation in induced adult mice
Formation of dendritic spines with GABAergic synapses by whisker stimulation in induced adult mice
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DOI：
10.1016/s0896-6273(02)00663-3
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发表时间：
2002-04-11
期刊：
影响因子：
16.2
通讯作者：
Welker, E
中科院分区：
文献类型：
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作者：
Knott, GW;Quairiaux, C;Welker, E
在发育过程中，感觉经验的改变会改变皮层神经元的结构，特别是在树突棘的水平。成人大脑皮层的可塑性是否也有类似的适应性？在这里，我们表明，在自由移动的成年小鼠24小时内的单须刺激增加，由36%，在相应的皮质桶的总突触密度。这是由于在棘上发现的兴奋性和抑制性突触的增加。刺激后4天，尽管总突触密度恢复到刺激前水平，但对棘的抑制性输入仍然存在。IV层细胞的功能分析表明，改变响应特性，刺激后立即，以及四天后。这些结果表明，成年后突触回路的活动依赖性改变，改变了进入大脑皮层的感觉信息流。
During development, alterations in sensory experience modify the structure of cortical neurons, particularly at the level of the dendritic spine. Are similar adaptations involved in plasticity of the adult cortex? Here we show that a 24 hr period of single whisker stimulation in freely moving adult mice increases, by 36%, the total synaptic density in the corresponding cortical barrel. This is due to an increase in both excitatory and inhibitory synapses found on spines. Four days after stimulation, the inhibitory inputs to the spines remain despite total synaptic density returning to pre-stimulation levels. Functional analysis of layer IV cells demonstrated altered response properties, immediately after stimulation, as well as four days later. These results indicate activity-dependent alterations in synaptic circuitry in adulthood, modifying the flow of sensory information into the cerebral cortex.