Response to "Two Bad Diets for Monkeys".
Response to "Two Bad Diets for Monkeys".
复制标题
回应“猴子的两种不良饮食”。
DOI：
10.1002/oby.22587
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Register,ThomasC
中科院分区：
文献类型：
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作者：
Shively,CarolA;Appt,SusanE;Vitolins,MaraZ;Uberseder,Beth;Michalson,KristoferT;Silverstein-Metzler,MarnieG;Register,ThomasC
动物营养学研究是有价值的，因为与人类研究不同，我们可以确切地知道消耗了什么和多少。这种研究在评估长期消费的影响时特别有价值，因为人类的长期研究必须依赖自我报告，而自我报告可能不准确(1-3)。近年来，随着人们认识到多种营养物质相互作用会影响健康，研究转向了饮食模式，而不是个别的饮食成分。为了在对照实验中研究饮食模式，饮食成分必须以这样一种方式呈现，即研究参与者不能在饮食成分中挑选。因此，在临床前营养实验中，它们通常被混合在一起，就像在这个实验中(6)。这两种饮食的成分都是人级的，通常用于人类消费的食物中(除了维生素和矿物质的混合物，这是明确为完全的猕猴营养而制成的)(6)。高质量的食品级特级初榨橄榄油与核桃一起使用，以平行于地中海饮食预防(PREDIMED)研究中使用的饮食变量(4)。这些核桃是从一家生产核桃供人类食用的核桃公司获得的，其中包括可以与其他原料均匀混合的碎核桃
Animal nutrition studies are valuable because, unlike in human studies, we can know exactly what and how much was consumed. Such studies are especially valuable when assessing the effects of long-term consumption because human long-term studies must rely on self-report, which may not be accurate (1-3). In recent years, study has turned to diet patterns rather than individual diet constituents, with the recognition that multiple nutrients interact to affect health. To study diet patterns in a controlled experiment, dietary constituents must be presented in such a way that the study participants cannot pick and choose among the diet components. Thus, they are typically mixed together in preclinical nutrition experiments, as in this experiment (6).The ingredients of both diets were human grade and routinely used in food produced for human consumption (save the vitamin and mineral mix, which is expressly made to complete macaque nutrition)(6). Highquality, food-grade extra-virgin olive oil was used along with walnuts in order to parallel dietary variables used in the Prevention with Mediterranean Diet (PREDIMED) study (4). The walnuts were obtained from a walnut company that produces walnuts for human consumption, including ground walnuts that can be mixed uniformly with other ingredients