Extracorporeal treatment of acute renal failure in the intensive care unit: a critical view
Extracorporeal treatment of acute renal failure in the intensive care unit: a critical view
复制标题
重症监护病房急性肾衰竭的体外治疗：批判性观点
DOI：
--
复制
发表时间：
2004
影响因子：
38.9
通讯作者：
P. Ferdinande
中科院分区：
文献类型：
--
作者：
M. Schetz;Peter Lauwers;P. Ferdinande
重症患者的急性肾功能衰竭很少是一个孤立的问题，但更通常与多器官功能衰竭。当选择体外肾脏替代疗法时，必须考虑到这些其他衰竭器官。因此，在需要重症监护的患者中选择人工肾取决于该技术的疗效及其对脑、肺和心血管功能的可能不良影响。发生失衡综合征、动脉低氧血症和低血压的最重要致病因素是治疗时机、扩散性溶质转移、生物不相容膜和某些特定透析液组分（缓冲液、电解质浓度）。重要的是要了解这些因素发挥其不利影响的机制。将这些病理生理学机制应用于个体患者的心肺和神经系统状态允许预测其临床结果。这种方法将导致个体化的治疗选择，从而避免有害的副作用而不丧失疗效。
Acute renal failure in critically ill patients is seldom an isolated problem but is more usually associated with multiple organ failure. When choosing an extracoporeal kidney replacement therapy, these other failing organs must be taken into account. Therefore the choice of an artificial kidney in patients requiring intensive care depends on both the efficacy of the technique and its possible adverse effects on cerebral, pulmonary and cardiovascular function. The most important pathogenic factors in the development of dysequilibrium syndromes, arterial hypoxemia and hypotension are treatment timing, diffusive solute transfer, bio-incompatible membranes and some specific dialysate components (buffer, electrolyte concentrations). It is important to understand the mechanisms by which these factors exert their adverse effects. Application of these pathophysiological mechanisms to the cardiopulmonary and neurologic status of the individual patient permits the prediction of their clinical outcome. This approach will lead to individualised treatment selection, thereby avoiding deleterious side-effects without loss of efficacy.
Interleukin-1 及其与血液透析患者的相关性。
DOI：
--
发表时间：
1988
期刊：
Kidney international. Supplement
影响因子：
--
作者：
Dinarello,CA;Koch,KM;Shaldon,S
通讯作者：
Shaldon,S