Senescence and the SASP: many therapeutic avenues.
Senescence and the SASP: many therapeutic avenues.
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DOI：
10.1101/gad.343129.120
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发表时间：
2020-12-01
影响因子：
10.5
通讯作者：
Gil J
中科院分区：
文献类型：
--
作者：
Birch J;Gil J
在这篇综述中，Birch和Gil总结了衰老相关分泌表型（SASP）的调节和功能，并强调了SASP调节作为补充或替代当前衰老清除方法的治疗潜力。细胞衰老是一种应激反应，会引起细胞周期永久停滞并引发深刻的表型变化，例如生物活性分泌组的产生，称为衰老相关分泌表型（SASP）。急性衰老诱导可预防癌症并限制纤维化，但挥之不去的衰老细胞会导致与年龄相关的疾病。因此，靶向衰老细胞以延缓衰老和限制功能障碍，被称为“衰老疗法”，正在获得动力。虽然选择性杀死衰老细胞的药物（称为“senolytics”）是一个主要焦点，但以SASP为中心的方法正在成为靶向衰老相关疾病的替代方案。在这里，我们总结了SASP的调节和功能，并强调了SASP调节作为补充或替代目前senolytic方法的治疗潜力。
In this review, Birch and Gil summarize the regulation and functions of senescence-associated secretory phenotype (SASP) and highlight the therapeutic potential of SASP modulation as complimentary, or an alternative to, current senolytic approaches. Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay aging and limit dysfunction, known as “senotherapy,” is gaining momentum. While drugs that selectively kill senescent cells, termed “senolytics” are a major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarize the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary or an alternative to current senolytic approaches.
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影响因子：
16.6
作者：
Fuhrmann-Stroissnigg H;Ling YY;Zhao J;McGowan SJ;Zhu Y;Brooks RW;Grassi D;Gregg SQ;Stripay JL;Dorronsoro A;Corbo L;Tang P;Bukata C;Ring N;Giacca M;Li X;Tchkonia T;Kirkland JL;Niedernhofer LJ;Robbins PD
通讯作者：
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影响因子：
64.8
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DOI：
10.15252/embj.201592862
发表时间：
2016-04-01
期刊：
The EMBO journal
影响因子：
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通讯作者：
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影响因子：
82.9
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Khosla S
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
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作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J