New Insight on the Role of Plasminogen Receptor in Cancer Progression.
New Insight on the Role of Plasminogen Receptor in Cancer Progression.
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DOI：
10.4137/cgm.s27335
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Malla R
中科院分区：
文献类型：
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作者：
Kumari S;Malla R
纤溶酶原系统在组织再生、伤口愈合、免疫反应、血管生成、侵袭和转移等生理和病理过程中发挥重要作用。当纤溶酶原与其细胞表面受体结合时，它就会被激活。本文就一些已被广泛研究的纤溶酶原受体，如膜联蛋白II-S100A10、细胞角蛋白8、α-烯醇化酶、纤溶酶原受体(KT)(PLG-R(KT))和组蛋白H_2B的最新研究进展作一综述。这些受体可以为有效的治疗和诊断策略铺平道路，以对抗恶性疾病。本文综述了纤溶酶原受体在细胞外基质降解、侵袭周围组织、新生血管、侵袭、转移和耐药中的关键作用。本文还讨论了用单抗和DNA疫苗封闭这些纤溶酶原受体，或用小干扰RNA或短发夹状RNA沉默纤溶酶原受体基因以对抗肿瘤侵袭和转移的可能作用。
Plasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration, wound healing, immune response, angiogenesis, invasion and metastasis. It gets activated when plasminogen associates with its cell surface receptors. Latest information on some of the well-explored plasminogen receptors such as annexin II–S100A10, cytokeratin 8, α-enolase, plasminogen receptor (KT) (Plg-R(KT)) and histone H2B has been discussed in the present review. These receptors can pave the way for effective new therapeutic and diagnostic strategies to counteract malignant diseases. The present review concludes the key role of plasminogen receptors in extracellular matrix degradation, infiltration into surrounding tissues, neovascularization, invasion, metastasis and drug resistance. This review also discusses the possible effect of blocking these plasminogen receptors with monoclonal antibodies and DNA-based vaccination or silencing plasminogen receptor gene using small interfering RNA or short hairpin RNA to counteract cancer invasion and metastasis.