Additive effects of ultraviolet radiation.
Additive effects of ultraviolet radiation.
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紫外线辐射的叠加效应。
DOI：
10.1097/00006324-198011000-00005
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Cullen,AP
中科院分区：
文献类型：
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作者：
Cullen,AP
使用5000 W氙-汞高压灯和双单色器在295 nm处产生3.3 nm半带通紫外（UV）辐射。用0.014 ~ 1.0J· cm-2的焦耳/cm-2照射兔眼，裂隙灯生物显微镜观察。角膜阈值（HC）为0.0 5 J· cm-2，透镜阈值（HL）为0.75 J· cm-2。其他眼睛用2 H c照射，并在4小时间隔4小时从4到24小时进行评价。经过4小时的潜伏期，观察到角膜反应增加到最大值由12 hr. Additional眼睛进行重复H c和0.5 H c，然后由H c曝光与曝光之间的不同间隔。角膜损伤仅大于预期从一个单一的H c曝光，如果两个H c曝光之间的间隔不超过8小时。阈下曝光不敏感的角膜后H c照射。对这些紫外线水平的最可重复和可靠的角膜反应是角膜上皮颗粒的发育。
A 5000 W xenon-mercury high pressure lamp and a double monochromator were used to produce a 3.3-nm half-bandpass ultraviolet (UV) radiation at 295 nm. Pigmented rabbit eyes were irradiated with radiant exposures given in joules per cm 2 and ranging from 0.014 to 1.0 J• cm-2 and evaluated by slitlamp biomicroscopy. Corneal threshold (H c) was 0.05 J• cm-2 and lens threshold (H L) was 0.75 J• cm-2. Other eyes were irradiated with 2 H c and evaluated from 4 to 24 hr at 4-hr intervals. After a latent period of 4 hr, the corneal response was observed to increase to a maximum by 12 hr. Additional eyes were subjected to repeated H c and 0.5 H c followed by H c exposures with varying intervals between exposures. Corneal damage was only greater than that expected from a single H c exposure if the separation between the two H c exposures did not exceed 8 hr. The subthreshold exposures did not sensitize the cornea to later H c irradiations. The most repeatable and reliable corneal response to these levels of UV was the development of corneal epithelial granules.