The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm
The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm
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DOI：
10.1242/dev.062240
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发表时间：
2011-03-15
期刊：
影响因子：
4.6
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Tian, Chenxi;Shi, Herong;Liu, Jun
多细胞生物的正常发育需要细胞命运规范、细胞增殖和分化的精确调控和协调。这些过程的异常调节和协调可能导致包括癌症在内的疾病。我们研究了M谱系中唯一的秀丽隐杆线虫SoxC蛋白SEM-2的功能，该蛋白产生胚胎后中胚层。我们发现SEM-2/SoxC对于促进成肌细胞的增殖是必要和充分的，而不是分化的横纹肌。许多因素控制着性成肌细胞前体及其后代中sem-2的特异性表达。这包括通过Hox-PBC复合物直接控制sem-2的表达。HOX/PBC因子在秀丽隐杆线虫M系中直接增强这种增殖因子表达的关键性质表明，HOX -PBC因子和SoxC蛋白在调节细胞增殖方面可能存在更普遍的联系。
The proper development of multicellular organisms requires precise regulation and coordination of cell fate specification, cell proliferation and differentiation. Abnormal regulation and coordination of these processes could lead to disease, including cancer. We have examined the function of the sole C. elegans SoxC protein, SEM-2, in the M lineage, which produces the postembryonic mesoderm. We found that SEM-2/SoxC is both necessary and sufficient to promote a proliferating blast cell fate, the sex myoblast fate, over a differentiated striated bodywall muscle fate. A number of factors control the specific expression of sem-2 in the sex myoblast precursors and their descendants. This includes direct control of sem-2 expression by a Hox-PBC complex. The crucial nature of the HOX/PBC factors in directly enhancing expression of this proliferative factor in the C. elegans M lineage suggests a possible more general link between Hox-PBC factors and SoxC proteins in regulating cell proliferation.