Determinants of the diurnal course of salivary alpha-amylase
Determinants of the diurnal course of salivary alpha-amylase
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DOI：
10.1016/j.psyneuen.2007.02.007
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发表时间：
2007-05-01
影响因子：
3.7
通讯作者：
Kirschbaum, Clemens
中科院分区：
文献类型：
--
作者：
Nater, Urs M.;Rohleder, Nicolas;Kirschbaum, Clemens
目的：本研究组和其他研究组先前的数据表明，唾液α-淀粉酶活性在应激反应中增加。有人认为，唾液α-淀粉酶可能是肾上腺素能活性的标志物。对唾液α-淀粉酶激活的其他决定因素知之甚少。本研究的目的是描述唾液淀粉酶的昼夜模式及其determinants.Methods：唾液样本收集后立即唤醒，30和60分钟后，和每一个完整的0900和2000小时之间的76名健康志愿者（44名女性，32名男性）。遵守情况由电子监控器控制。为了控制可能影响唾液α-淀粉酶昼夜变化的因素，（如瞬间的压力，情绪，食物，或身体活动），在每个采样时间点，受试者配备了一个日记检查他们在前一个小时进行的活动。结果：唾液α-淀粉酶活性显示出明显的昼夜分布模式，在觉醒后60分钟内显著降低，并且在一天的过程中活性稳定增加。混合模型表明，白天唾液α-淀粉酶的相对独立的瞬时压力和其他因素，但与慢性压力和mood.Conclusions显着协会：我们的研究结果表明，白天的唾液α-淀粉酶的配置文件是相对强大的瞬间的影响，因此可能被证明是有用的交感神经系统活动的评估。这些发现强调了在使用唾液α-淀粉酶作为因变量的研究中需要控制一天中的时间。(C)2007爱思唯尔有限公司保留所有权利。
Objective: Previous data from our group and others have shown that salivary alpha-amylase activity increases in response to stress. It has been suggested that salivary alpha-amylase may be a marker for adrenergic activity. Less is known about other determinants of salivary alpha-amylase activation. The objective of the current study was to describe the diurnal pattern of salivary amylase and its determinants.Methods: Saliva samples were collected immediately after waking-up, 30 and 60 min later, and each full hour between 0900 and 2000 h by 76 healthy volunteers (44 women, 32 men). Compliance was controlled by electronic monitors. In order to control factors which might influence the diurnal profile of salivary alpha-amylase (such as momentary stress, mood, food, or body activity), at each sampling time point the subjects fitted out a diary examining the activities they had carried out during the previous hour.Results: Salivary alpha-amylase activity shows a distinct diurnal profile pattern with a pronounced decrease within 60min after awakening and a steady increase of activity during the course of the day. Mixed models showed a relative independence of diurnal salivary alpha-amylase from momentary stress and other factors, but significant associations with chronic stress and mood.Conclusions: Our results suggest that diurnal profiles of salivary alpha-amylase are relatively robust against momentary influences and therefore may prove useful in the assessment of sympathetic nervous system activity. The findings underscore the need to control for time of day in studies using salivary alpha-amylase as a dependent variable. (C) 2007 Elsevier Ltd. All rights reserved.