Risk counselling for family members in bipolar disorder and schizophrenia.
Risk counselling for family members in bipolar disorder and schizophrenia.
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为双相情感障碍和精神分裂症家庭成员提供风险咨询。
DOI：
10.1017/s1461145712001150
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Gershon,ElliotS
中科院分区：
文献类型：
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作者：
Gershon,ElliotS
在双相情感障碍（BD）和精神分裂症（SZ）中，罕见的和新生的染色体微缺失和微重复（CNVs）对风险有很大影响。对于福尔德novoCNVs，BD或SZ的风险为10%，而对于22号染色体上q11区域的缺失，这些疾病的风险为77%。少数BD和SZ患者发生这些类型的事件（4-6.5%）。心理治疗干预可能需要家庭内的耻辱和冲突的基因检测结果。这些发现还提出了关于预防污名化、人口筛查和基于基因型的堕胎的伦理问题。
In bipolar disorder (BD) and schizophrenia (SZ) rare andde novochromosomal microdeletions and microduplications (CNVs) have strong effects on risk. Forde novoCNVs, the risk of BD or SZ is 10% and for deletions of the q11 region on chromosome 22, the risk of either of these disorders is 77%. A not-insignificant minority of BD and SZ patients have these types of event (4–6.5%). Psychotherapeutic intervention may be needed for within-family stigma and conflicts over genetic test results. These findings also raise ethical issues on stigma prevention, population screening, and abortion based on genotype.