Fabrication of alternating polycation and albumin multilayer coating onto stainless steel by electrostatic layer-by-layer adsorption
Fabrication of alternating polycation and albumin multilayer coating onto stainless steel by electrostatic layer-by-layer adsorption
复制标题
DOI：
10.1016/j.colsurfb.2003.12.015
复制
发表时间：
2004-04-01
影响因子：
5.8
通讯作者：
Shen, JC
中科院分区：
文献类型：
--
作者：
Ji, JA;Tan, QG;Shen, JC
Multilayer films consisting of polyethylenimme (PEI) and albumin were successfully prepared on biomedical 316L stainless steel surface via electrostatic self-assembly of the PEI and albumin. The process of electrostatic self-assembly of PEI/albumin was monitored by 1 25 1 radiolabeling, electrochemical impedance spectroscopy (EIS) and atomic force microscopy (AFM). The EIS data revealed that the multilayer coating was stable in Tris-HCl (pH 7.35) buffer solution for 21 days. I-125 radiolabeling experiments indicated that less than 10% albumin was eluted by PBS in 45 days. Static platelet adhesion experiments indicated that the PEI/albumin deposited on stainless steel could resist platelet adhesion effectively. Such an easy processing and shape-independent method may have good potential for surface modification of cardiovascular devices. (C) 2004 Elsevier B.V. All rights reserved.
