Healthy Subjects Differentially Respond to Dietary Capsaicin Correlating with Specific Gut Enterotypes
Healthy Subjects Differentially Respond to Dietary Capsaicin Correlating with Specific Gut Enterotypes
复制标题
健康受试者对与特定肠道肠型相关的膳食辣椒素的不同反应
DOI：
10.1210/jc.2016-2786
复制
发表时间：
2016-12-01
影响因子：
5.8
通讯作者：
Mi, Mantian
中科院分区：
文献类型：
--
作者：
Kang, Chao;Zhang, Yong;Mi, Mantian
内容：以往的人群研究在评价辣椒素（CAP）的有益作用方面取得了不确定的结果，其可能的作用机制仍不清楚。目的：本研究的目的是评估饮食CAP对健康成人代谢和免疫特征的影响及其与肠道微生物模式的潜在关联。设计：在为期6周的控制喂养试验中，受试者依次给予含有0、5、0和10 mg/d辣椒粉CAP的体重维持饮食。研究对象为重庆市第三军医大学12名健康志愿者，主要指标：每个疗程结束时，采集血液和粪便标本，进行人体测量和基础代谢测定。结果：CAP可增加厚壁菌门/拟杆菌门比值和粪杆菌属丰度，同时可增加血浆胰高血糖素样肽1和胃抑制多肽水平，降低血浆ghrelin水平。进一步的肠型分析显示，这些受试者可分为肠型拟杆菌（E1）和肠型普雷沃菌（E2），上述有益效果主要在E1受试者中获得。结论：肠道菌型可能影响CAP的膳食效应，为CAP干预的个体化营养指导提供了新的依据。
Context: Previous population studies in evaluating the beneficial effects of capsaicin (CAP) have yielded inconclusive results, and the mechanisms responsible for possible benefit remain unclear.Objective: The objective was to assess the effect of dietary CAP on metabolic and immune profiles and its potential associations with gut microbial patterns in healthy adults.Design: In a 6-week controlled feeding trial, subjects were given the weight maintenance diet sequentially contained with 0, 5, 0, and 10 mg/d CAP from chili powder.Setting and Participants: The study was conducted in 12 healthy subjects enrolled in Third Military Medical University in Chongqing.Main Outcome Measures: At the end of each period, anthropometric and basal metabolism measures together with blood and fecal samples were collected. Plasma metabolic and inflammatory markers and gut microbial ecology of each subject were subsequently assessed.Result: Dietary CAP increased the Firmicutes/Bacteroidetes ratio and Faecalibacterium abundance, accompanied with increased plasma levels of glucagon-like peptide 1 and gastric inhibitory polypeptide and decreased plasma ghrelin level. Further enterotype analysis revealed that these subjects could be clustered into Bacteroides enterotype (E1) and Prevotella enterotype (E2), and the above beneficial effects were mainly obtained in E1 subjects. Moreover, E1 subjects had significantly higher fecal Faecalibacterium abundance and butyrate concentration after CAP interventions than those in E2 subjects.Conclusion: Our study showed that gut enterotypes may influence the beneficial effects of dietary CAP, providing new evidence for the personalized nutrition guidance of CAP intervention on health promotion linking with gut microbiota patterns.