Relationships between serum irisin levels and metabolic parameters in Japanese patients with obesity.
Relationships between serum irisin levels and metabolic parameters in Japanese patients with obesity.
复制标题
DOI：
10.1002/osp4.43
复制
发表时间：
2016-06
影响因子：
2.2
通讯作者：
Kimura, Yutaka
中科院分区：
文献类型：
--
作者：
Fukushima, Yaeko;Kurose, Satoshi;Shinno, Hiromi;Cao Thi Thu, Ha;Tamanoi, Atsuko;Tsutsumi, Hiromi;Hasegawa, Takaaki;Nakajima, Toshiaki;Kimura, Yutaka
Irisin是一种骨骼肌肌因子，其引起白色脂肪的棕色着色，促进脂肪燃烧，抑制体重增加，并且可用于治疗肥胖症。鸢尾素也与葡萄糖/脂质代谢有关，并可预防糖尿病的发生，但对鸢尾素的分泌尚未达成共识。本研究的目的是确定未经治疗的日本肥胖男性和女性的血清鸢尾素水平和身体因素之间的关系。受试者为66名未经治疗的肥胖患者（体重指数≥30 kg m−2），他们都曾到我们的肥胖诊所就诊。受试者包括19名男性和47名女性，平均年龄为45.7 ± 13.4岁，平均体重为93.8 ± 17.6 kg，平均体重指数为36.5 ± 4.7 kg m−2。在首次访视时，进行血液采样，使用双能X线吸收测定法评价身体成分，并在心肺运动试验中测定运动耐量。测量稳态评估模型-胰岛素抵抗（HOMA-IR）（胰岛素抵抗的指标）和血清鸢尾素水平。在男性中，血清鸢尾素与空腹血糖呈正相关（r = 0.491，P < 0.05），免疫反应性胰岛素（r = 0.536，P < 0.05），HOMA-IR（r = 0.635，P < 0.01），体重（r = 0.491，P < 0.05）、躯干瘦体重（r = 0.579，P < 0.05）和整体瘦体重（r = 0.489，P < 0.05）。女性患者血清鸢尾素水平与免疫反应性胰岛素（r = 0.502，P < 0.01）和HOMA-IR（r = 0.385，P < 0.01）呈正相关。在两种性别中，HOMA-IR是与肥胖相关的独立变量（男性：β = 0.635，R2 = 0.369，P < 0.01;女性：β = 0.385，R2 = 0.129，P < 0.01）。在日本男女肥胖患者中，血清鸢尾素水平与HOMA-IR呈正相关。这表明，补偿性增强的鸢尾素分泌可能会发生在胰岛素抵抗。在肥胖男性中，血清鸢尾素水平与空腹血糖水平、免疫反应性胰岛素和稳态评估模型-胰岛素抵抗（HOMA-IR）呈正相关。在肥胖女性中，血清鸢尾素水平与免疫反应性胰岛素和HOMA-IR呈正相关。在逐步多元线性回归分析中，HOMA-IR是与肥胖相关的自变量。在胰岛素抵抗时，可能会发生鸢尾素分泌的代偿性增强。
Irisin is a skeletal muscle myokine that causes the brown coloration of white fat, promotes fat burning, inhibits weight gain and may be useful for treatment of obesity. Irisin is also related to glucose/lipid metabolism and may prevent onset of diabetes, but a consensus on irisin secretion has not been reached. The purpose of this study was to determine the relationships between serum irisin levels and physical factors in untreated Japanese men and women with obesity. The subjects were 66 untreated patients with obesity (body mass index ≥30 kg m−2) who visited our obesity clinic. The subjects included 19 men and 47 women with a mean age of 45.7 ± 13.4 years, mean body weight of 93.8 ± 17.6 kg, and mean body mass index of 36.5 ± 4.7 kg m−2. At the initial visit, blood sampling was performed, body composition was evaluated using dual energy X‐ray absorptiometry, and exercise tolerance was determined in a cardiopulmonary exercise test. Homeostasis model of assessment – insulin resistance (HOMA‐IR), an index of insulin resistance, and the serum level of irisin were measured. In men, serum irisin was positively correlated with fasting blood glucose (r = 0.491, P < 0.05), immunoreactive insulin (r = 0.536, P < 0.05), HOMA‐IR (r = 0.635, P < 0.01), body weight (r = 0.491, P < 0.05), lean body mass of the trunk (r = 0.579, P < 0.05) and whole lean body mass (r = 0.489, P < 0.05). In women, serum irisin was positively correlated with immunoreactive insulin (r = 0.502, P < 0.01) and HOMA‐IR (r = 0.385, P < 0.01). In both sexes, HOMA‐IR was an independent variable associated with obesity (men: β = 0.635, R2 = 0.369, P < 0.01; women: β = 0.385, R2 = 0.129, P < 0.01). The serum level of irisin was positively correlated with HOMA‐IR in Japanese patients with obesity of both sexes. This suggests that compensatory enhancement of irisin secretion may occur in response to insulin resistance. In men with obesity, the serum irisin level was positively correlated with the fasting blood glucose level, immunoreactive insulin and homeostasis model of assessment – insulin resistance (HOMA‐IR). In women with obesity, the serum irisin level was positively correlated with immunoreactive insulin and HOMA‐IR. In stepwise multiple linear regression analysis, HOMA‐IR was an independent variable associated with obesity. Compensatory enhancement of irisin secretion may occur in response to insulin resistance.