Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats
Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats
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DOI：
10.1016/j.apradiso.2018.05.021
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发表时间：
2018-09-01
影响因子：
1.6
通讯作者：
Hatazawa, Jun
中科院分区：
文献类型：
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作者：
Ikeda, Hayato;Hayashi, Yoshihiko;Hatazawa, Jun
我们建议在临床前研究中使用astatine-210。与砹-211相比，砹-210的产量更高，且更容易量化。以Bi靶和回旋加速器加速40 MeV α束制备astatine-210，分离游离的astatine-210并注射到正常大鼠体内。3只雄性大鼠（阻断组）在注射砹-210前注射非放射性碘。与对照组相比，阻断组的阿斯丁-210在甲状腺中的蓄积量下降至24%。
We proposed use of astatine-210 in preclinical study. Astatine-210 has higher yield of production and is easier to quantify than astatine-211. We produced astatine-210 with Bi target and 40 MeV alpha beam accelerated by cyclotron, free astatine-210 was separated and injected to normal rats. Three male rats (blocking group) were injected non-radioactive iodide before injection of astatine-210. Compared with the control group, the astatine-210 accumulations in the blocking group decreased to 24% in the thyroid.