Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder.
Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder.
复制标题
广泛型社交焦虑症患者电刺激应激后唾液α-淀粉酶和皮质醇的反应性。
DOI：
10.1055/s-0033-1353157
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Akiyoshi J.
中科院分区：
文献类型：
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作者：
Tamura A;Maruyama Y;Ishitobi Y;Kawano A;Ando T;Ikeda R;Inoue A;Imanaga J;Okamoto S;Kanehisa M;Ninomiya T;Tanaka Y;Tsuru J;Akiyoshi J.
社交焦虑症被认为是一种由压力引起的疾病。虽然从社交焦虑症发作时的症状可以推断其任何一个应激系统都存在自主神经系统的异常，但证据很少。本研究旨在比较社交焦虑障碍患者自主神经系统（ANS）和下丘脑-垂体-肾上腺（HPA）轴两种应激系统的反应性。将32例广泛型社交焦虑障碍患者与80例年龄和性别匹配的对照组进行比较。我们收集了患者和对照组在电刺激前后的唾液样本，以测量唾液α-淀粉酶（sAA）和唾液皮质醇的浓度。在刺激后还测定了情绪状态（POMS）和状态-特质焦虑量表（STAI）评分以及心率变异性（HRV），与对照组相比，患者的SAA在基线时显示出显著更高的水平，对电刺激的反应显著更大，而在任何HRV中均未观察到组间差异。这些结果表明，SAD患者与健康对照组相比，ANS（而非HPA轴）活动增强。
Social anxiety disorder is believed to be a stress-induced disease. Although it can be inferred from the symptoms during attacks that there exists some abnormality of autonomic nervous system in any of the stress systems in social anxiety disorder, little evidence has been reported. This study focused on comparing the reactivity of 2 stress systems, the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis in patients with social anxiety disorder.32 patients with the generalized type of social anxiety disorder were compared with 80 age- and gender-matched controls. We collected saliva samples from patients and controls before and after electrical stimulation to measure the concentrations of salivary alpha-amylase (sAA) and salivary cortisol. Profile of Mood State (POMS) and State-Trait Anxiety Inventory (STAI) scores and Heart Rate Variability (HRV) were also determined following stimulation.SAA in patients displayed a significantly higher level at baseline and a significantly larger response to electrical stimulation as compared to controls, whereas no group differences were seen in any HRV. Neither within-subject nor group differences were seen in salivary cortisol levels.These results suggest that SAD patients displayed enhanced ANS (but not HPA axis) activity vs. healthy controls.