Atherosclerosis : Vascular biology
Atherosclerosis : Vascular biology
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作者：
A. Lusis
动脉粥样硬化是一种大动脉疾病，是心脏病和中风的主要原因。在...在西方社会中，它是约50%死亡的根本原因。流行病学研究揭示了与动脉粥样硬化相关的几个重要的环境和遗传危险因素。然而，在确定所涉及的细胞和分子相互作用方面的进展受到了疾病病因学复杂性的阻碍。在过去的十年中，新的研究工具，包括转基因小鼠疾病模型的可用性，导致了对胆固醇代谢改变和其他危险因素与动脉粥样硬化斑块发展之间联系的分子机制的更清楚的理解。现在清楚的是，动脉粥样硬化不仅仅是衰老的不可避免的退行性后果，而是一种慢性炎症性疾病，可以通过斑块破裂和血栓形成转化为急性临床事件。
Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. In ..... westernized societies, it is the underlying cause of about 50% of all deaths. Epidemiological studies have revealed several important environmental and genetic risk factors associated with atherosclerosis. Progress in defining the cellular and molecular interactions involved, however, has been hindered by the disease's aetiological complexity. Over the past decade, the availability of new investigative tools, including genetically modified mouse models of disease, has resulted in a clearer understanding of the molecular mechanisms that connect altered cholesterol metabolism and other risk factors to the development of atherosclerotic plaque. It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis.