In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease
In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease
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DOI：
10.1212/01.wnl.0000138434.68093.67
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发表时间：
2004-09-28
期刊：
影响因子：
9.9
通讯作者：
Jernigan, TL
中科院分区：
文献类型：
--
作者：
Fennema-Notestine, C;Archibald, SL;Jernigan, TL
目的：利用结构 MRI 的形态测量分析，研究亨廷顿病 (HD) 中白质和小脑变化以及皮质下和皮质变化的区域模式。方法：对 15 名 HD 患者和 22 名对照者进行了研究；各组的年龄和教育程度相似。初步分析定义了六个皮质下区域、初级皮质叶和小脑的灰质和白质，以及大脑白质中的异常信号。结果：正如预期的那样，HD 患者的基底神经节和大脑皮质灰质体积明显较小。 HD组还表现出明显的脑白质损失以及白质中异常信号数量的增加；枕叶白质似乎比其他大脑白质区域更受影响。皮质灰质和白质测量与尾状核体积显着相关。 HD 中小脑灰质和白质体积均较小。结论：小脑和脑白质的完整性可能在 HD 症状中发挥比以前认为更重要的作用。此外，皮质灰质和大脑白质的变化与尾状核萎缩有关，支持类似的退化机制。
Objective: To investigate the regional pattern of white matter and cerebellar changes, as well as subcortical and cortical changes, in Huntington disease (HD) using morphometric analyses of structural MRI. Methods: Fifteen individuals with HD and 22 controls were studied; groups were similar in age and education. Primary analyses defined six subcortical regions, the gray and white matter of primary cortical lobes and cerebellum, and abnormal signal in the cerebral white matter. Results: As expected, basal ganglia and cerebral cortical gray matter volumes were significantly smaller in HD. The HD group also demonstrated significant cerebral white matter loss and an increase in the amount of abnormal signal in the white matter; occipital white matter appeared more affected than other cerebral white matter regions. Cortical gray and white matter measures were significantly related to caudate volume. Cerebellar gray and white matter volumes were both smaller in HD. Conclusions: The cerebellum and the integrity of cerebral white matter may play a more significant role in the symptomatology of HD than previously thought. Furthermore, changes in cortical gray and cerebral white matter were related to caudate atrophy, supporting a similar mechanism of degeneration.