Use of FTIR Spectroscopic Imaging to Identify Parameters Associated With Fragility Fracture
Use of FTIR Spectroscopic Imaging to Identify Parameters Associated With Fragility Fracture
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DOI：
10.1359/jbmr.090414
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发表时间：
2009-09-01
影响因子：
6.2
通讯作者：
Boskey, Adele L.
中科院分区：
文献类型：
--
作者：
Gourion-Arsiquaud, Samuel;Faibish, Dan;Boskey, Adele L.
骨密度并不能完全解释个体的骨折风险。本研究的目的是评估空间分解骨成分的特定差异是否也会导致骨折风险。这些差异采用傅里叶变换红外光谱成像（FTIRI）进行评估，并通过多元逻辑回归进行分析。构建模型以确定FTIRI测量的参数是否描述矿物含量、矿物晶体大小和完美度以及胶原成熟度与骨折相关。皮质骨和松质骨在54名女性（32名骨折，22名未骨折）的髂骨活检中进行了独立评估，这些女性的脊柱骨密度明显不同，但髋部骨密度不同，年龄从30岁到83岁不等。模型中与骨折显著相关的参数是皮质和松质胶原成熟度（骨折风险增加而增加），皮质矿物/基质比（骨折风险增加而增加），松质结晶度（随着骨折风险的增加而增加）。正如预期的那样，由于髋部骨密度与皮质而非松质骨密度相关，因此在皮质而非松质模型中，髋部骨密度与骨折风险显著相关。这项研究表明，骨质疏松症的治疗应该针对与骨折风险相关的其他参数。[J]中华骨科学杂志，2009;24(4):559 - 561。2009年4月27日在线发布；doi: 10.1359 / JBMR.090414
BMD does not entirely explain an individual's risk of fracture. The purpose of this study was to assess whether specific differences in spatially resolved bone composition also contribute to fracture risk. These differences were assessed using Fourier transform infrared spectroscopic imaging (FTIRI) and analyzed through multiple logistic regression. Models were constructed to determine whether FTIRI measured parameters describing mineral content, mineral crystal size and perfection, and collagen maturity were associated with fracture. Cortical and cancellous bone were independently evaluated in iliac crest biopsies from 54 women (32 with fractures, 22 without) who had significantly different spine but not hip BMDs and ranged in age from 30 to 83 yr. The parameters that were significantly associated with fracture in the model were cortical and cancellous collagen maturity (increased with increased fracture risk), cortical mineral/matrix ratio (higher with increased fracture risk), and cancellous crystallinity (increased with increased fracture risk). As expected, because of its correlation with cortical but not cancellous bone density, hip BMD was significantly associated with fracture risk in the cortical but not the cancellous model. This research suggests that additional parameters associated with fracture risk should be targeted for therapies for osteoporosis. J Bone Miner Res 2009;24:1565-1571. Published online on April 27, 2009; doi: 10.1359/JBMR.090414