Facilitative effect of a glutamate transporter inhibitor (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate on the expression of methamphetamine-induced behavioral sensitization in rats.
Facilitative effect of a glutamate transporter inhibitor (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate on the expression of methamphetamine-induced behavioral sensitization in rats.
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DOI：
10.1254/jphs.sc0050144
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发表时间：
2005
影响因子：
3.5
通讯作者：
M. Fujio;T. Nakagawa;Yuichi Suzuki;M. Satoh;S. Kaneko
中科院分区：
文献类型：
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作者：
M. Fujio;T. Nakagawa;Yuichi Suzuki;M. Satoh;S. Kaneko
我们研究了一种有效的谷氨酸转运体抑制剂(2S，3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate对甲基苯丙胺诱导的大鼠行为敏化表达的影响。大鼠以2 mg/kg甲基苯丙胺连续5d腹腔注射，然后以1 mg/kg甲基苯丙胺激发。激发前10min侧脑室注射TFB-TBOA(0.1nmoL)可显著促进行为敏化的表达。另一方面，对反复生理盐水处理(非致敏)大鼠甲基苯丙胺激发的运动兴奋无影响。这些结果提示，中枢谷氨酸转运体可能在甲基苯丙胺行为敏化表达中起抑制作用。
We examined the effects of a potent glutamate transporter inhibitor, (2S,3S)-3-{3-[4-(trifluoromethyl)benzoylamino]benzyloxy}aspartate (TFB-TBOA), on the expression of methamphetamine-induced behavioral sensitization in rats. Rats were intraperitoneally treated with 2 mg/kg methamphetamine for 5 days and then challenged with 1 mg/kg methamphetamine. Intracerebroventricular administration of TFB-TBOA (0.1 nmol) 10 min before the challenge significantly facilitated the expression of behavioral sensitization. On the other hand, it had no effect on the locomotor activation elicited by the challenge with methamphetamine in repeated-saline-treated (non-sensitized) rats. These results suggest that central glutamate transporters may play an inhibitory role in the expression of behavioral sensitization to methamphetamine.