The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases undergoing 90Y selective internal radiation therapy plus chemotherapy
The prognostic value of functional tumor volume and total lesion glycolysis in patients with colorectal cancer liver metastases undergoing 90Y selective internal radiation therapy plus chemotherapy
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DOI：
10.1007/s00259-011-1758-4
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发表时间：
2011-07-01
影响因子：
9.1
通讯作者：
Pennington, Kenneth
中科院分区：
文献类型：
--
作者：
Gulec, Seza A.;Suthar, Rekha R.;Pennington, Kenneth
Purpose Functional tumor volume (FTV) and total lesion glycolysis (TLG) are measures of metabolic activity of tumors determined by fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT images. These parameters could potentially have clinical value in response to treatment evaluation and disease prognostication. The objectives of this study were to investigate the relationship between functional tumor parameters (FTV and TLG) and clinical outcomes in patients with colorectal cancer liver metastases (CRCLM) undergoing Y-90-resin microsphere selective internal radiation therapy (SIRT) (SIR-Spheres(R), Sirtex Medical Limited, Lane Cove, NSW, Australia).Methods FDG PET/CT studies of 20 patients with unresectable CRCLM who underwent Y-90 SIRT under a phase II clinical trial were analyzed. FTV and TLG were calculated using PET VCAR (GE Healthcare, Milwaukee, WI, USA) on pretreatment and 4-week posttreatment scans. The effects of pretreatment and posttreatment functional tumor activity on patient survival were evaluated using Kaplan-Meier survival curves.Results The median survival in the study group was 14.8 months (range 2.0-27.7 months). The median survival for patients with pretreatment FTV values of above and below 200 cc were 11.2 and 26.9 months, respectively (p
