Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients
Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients
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DOI：
10.1159/000497069
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发表时间：
2019-01-01
影响因子：
2.9
通讯作者：
Kim, Young Dae
中科院分区：
文献类型：
--
作者：
Baik, Minyoul;Kim, Seung Up;Kim, Young Dae
背景：调查缺血性卒中或短暂性脑缺血发作（TIA）患者的长期全因死亡率和心血管死亡率是否因肝纤维化或脂肪变性负担而存在差异。 -方法：2014 年 1 月至 2014 年 12 月连续接受瞬时弹性成像 (TE) 的急性缺血性卒中或 TIA 患者被认为符合资格。使用 Cox 比例风险模型研究了通过 TE 评估的肝纤维化或脂肪变性对长期结果的影响。结果：本研究纳入的395名患者中，有37名（9%）患者出现明显纤维化（>8.0 kPa），164名（41.5%）患者患有脂肪肝（>250 dB/m）。在随访期间（中位 2.7 年），分别有 28 名（7.1%）和 20 名（5.1%）患者发生全因死亡和心血管死亡。多变量分析显示，显着的肝纤维化与全因死亡率（风险比 [HR] 8.14，95% CI 3.03-21.90，p < 0.001）和心血管死亡率（HR 4.29，95% CI 1.10-16.73，p = 0.036）风险增加独立相关，而脂肪肝则不然（全部 p > 0.05）。结论：本研究发现，通过 TE 评估的肝纤维化负担（而非脂肪变性负担）是缺血性中风患者长期随访期间全因死亡率和心血管死亡率的独立预测因子。 (c) 2019 S. Karger AG，巴塞尔
Background: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. Results: Among 395 patients included in this study, there were 37 (9%) patients with significant fibrosis (>8.0 kPa) and 164 (41.5%) patients with fatty liver (>250 dB/m). During the follow-up period (median 2.7 years), all-cause and cardiovascular mortality occurred in 28 (7.1%) and 20 (5.1%) patients. On multivariate analyses, significant liver fibrosis was independently associated with increased risk of all-cause ( hazard ratio [HR] 8.14, 95% CI 3.03-21.90, p < 0.001) and cardiovascular ( HR 4.29, 95% CI 1.10-16.73, p = 0.036) mortality, whereas fatty liver was not ( all p > 0.05). Conclusions: This study found that the burden of liver fibrosis but not that of steatosis, assessed via TE, was an independent predictor of all-cause and cardiovascular mortality during long-term follow-up in patients with ischaemic stroke. (c) 2019 S. Karger AG, Basel