Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis?
Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis?
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番茄中酮类胡萝卜素的产生触发代谢重编程和细胞适应：寻求体内平衡？
DOI：
10.1101/2023.01.09.523254
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Nogueira M
中科院分区：
文献类型：
--
作者：
Nogueira M
植物是无柄的，因此发展了一种非凡的能力来适应外部信号。在这里，重点是植物细胞的可塑性，以响应新的细胞内的线索。酮基类胡萝卜素是具有强效抗氧化活性的高价值天然红色素。在本研究中，系统水平的分析表明，番茄中酮类胡萝卜素的异源生物合成启动了一系列细胞和代谢机制，以科普植物非内源性代谢产物的形成。广泛的多层次的变化与，除其他外，（i）质体膜的重塑，其中酮类胡萝卜素的合成和存储发生;（ii）招募的核心代谢途径的代谢产物前体和能量的产生;和（iii）氧化还原控制。参与的代谢物作为调节细胞过程显示在这里加强了他们的关键作用，建议在重塑的“中心法则”的概念。此外，代谢重编程的作用，以确保细胞内稳态的建议。
Plants are sessile and therefore have developed an extraordinary capacity to adapt to external signals. Here, the focus is on the plasticity of the plant cell to respond to new intracellular cues. Ketocarotenoids are high‐value natural red pigments with potent antioxidant activity. In the present study, system‐level analyses have revealed that the heterologous biosynthesis of ketocarotenoids in tomato initiated a series of cellular and metabolic mechanisms to cope with the formation of metabolites that are non‐endogenous to the plant. The broad multilevel changes were linked to, among others, (i) the remodelling of the plastidial membrane, where the synthesis and storage of ketocarotenoids occurs; (ii) the recruiting of core metabolic pathways for the generation of metabolite precursors and energy; and (iii) redox control. The involvement of the metabolites as regulators of cellular processes shown here reinforces their pivotal role suggested in the remodelled ‘central dogma’ concept. Furthermore, the role of metabolic reprogramming to ensure cellular homeostasis is proposed.