Lung cancer risk and vitamin A consumption in New Mexico.
Lung cancer risk and vitamin A consumption in New Mexico.
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新墨西哥州的肺癌风险和维生素 A 消耗量。
DOI：
10.1164/arrd.1985.131.2.198
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Pathak,DR
中科院分区：
文献类型：
--
作者：
Samet,JM;Skipper,BJ;Humble,CG;Pathak,DR
在新墨西哥州的一项以人群为基础的病例对照研究中，研究人员对447名患者和759名对照组进行了研究，研究了饮食中维生素A摄入量与肺癌风险之间的关系。采用食物频率访谈法测量总维生素A、视黄醇、预成型维生素A和胡萝卜素的日常摄入量。综合所有受访者，肺癌的比值比随着总维生素A和胡萝卜素摄入量的下降而增加，但不随预形成维生素A摄入量的变化而变化。当受试者按种族群体分层，西班牙裔或非西班牙裔（盎格鲁）白人，维生素A摄入的显著影响仅限于盎格鲁人。在盎格鲁人中，维生素A和胡萝卜素的总摄入量对男性和女性都有保护作用，但吸烟习惯的差异很大。在英国吸烟者中，观察到前吸烟者的比值比随着摄入量的减少而显著增加，但在当前吸烟者中没有观察到。在戒烟者中，总维生素A和胡萝卜素摄入量的显著影响仅出现在戒烟6至15年的人群中。维生素A和胡萝卜素摄入量对戒烟者的保护作用的限制对临床试验的设计和癌症控制策略具有重要意义。
The association between dietary intake of vitamin A and lung cancer risk was examined in a population-based, case-control study of 447 patients and 759 control subjects in New Mexico. A food frequency interview was used to measure usual consumption of total vitamin A retinol, preformed vitamin A, and carotene. With all respondents combined, the odds ratios for lung cancer increased as intakes of total vitamin A and carotene declined but did not vary with intake of preformed vitamin A. When the subjects were stratified by ethnic group, Hispanic or non-Hispanic (Anglo) white, significant effects of vitamin A consumption were limited to the Anglos. In the Anglos, the protective effects of total vitamin A and carotene consumption were present in males and females, but varied strongly with cigarette smoking habits. In Anglo smokers, significant increases in the odds ratios with declining intake were observed in former but not in current smokers. Among the former smokers, significant effects of total vitamin A and carotene consumption were present only in those who had stopped smoking for 6 to 15 yr. Limitation of the protective effect of vitamin A and carotene consumption to past smokers has important implications for the design of clinical trials and for cancer control strategies.