Emerging mechanisms for exercise effects on muscle wasting and anabolic resistance.
Emerging mechanisms for exercise effects on muscle wasting and anabolic resistance.
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DOI：
10.1016/j.smhs.2020.11.001
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发表时间：
2020-12
影响因子：
--
通讯作者：
Greene NP
中科院分区：
文献类型：
--
作者：
Deaver JW;Greene NP
在2018年美国运动医学会年会上，Drs.尼古拉斯·P·格林 (Nicholas P. Greene)、詹姆斯·A·卡森 (James A. Carson) 和詹姆斯·D·弗拉基 (James D. Fluckey) 在题为“锻炼对肌肉萎缩和合成代谢抵抗的影响的新兴机制”的研讨会上。受本次研讨会演讲的启发，精心编写了以下综述，以探讨当前对以肌肉萎缩和合成代谢抵抗为特征的肌肉疾病的理解，特别是它们的识别、发展、进展和缓解。如今，全球每 6 例死亡中就有 1 例死于癌症，1 并且高达 40% 的癌症相关死亡可直接归因于癌症恶病质。 2, 3, 4, 5 Greene 博士小组（Lim 等人）的综述概述了癌症恶病质的观点。随后，Carson 博士小组（Halle 等人）的工作扩展了癌症恶病质的概念，更具体地检查肌肉，以及运动如何作为癌症恶病质的对策。最后，Fluckey 博士小组（Deaver 等人）的工作评估了合成代谢的调节，特别关注 mRNA 翻译，这是维持骨骼肌质量的一个关键方面。虽然这些评论的灵感和总体主题是一致的，但每一篇评论都提供了独特的视角，并且共同代表了当前有关骨骼肌消耗疾病的文献的令人兴奋的概述。这篇社论对每条评论进行了简要介绍。
At the 2018 Annual Meeting of the American College of Sports Medicine, presentations were given by Drs. Nicholas P. Greene, James A. Carson, and James D. Fluckey, at a symposium titled “Emerging Mechanisms for Exercise Effects on Muscle Wasting and Anabolic Resistance”. Inspired by the presentations at this symposium, the following reviews have been crafted to examine the current understanding of muscle diseases characterized by muscle wasting and anabolic resistance, particularly their identification, development, progression, and mitigation. Today, cancer accounts for roughly 1 in every 6 deaths worldwide, 1 and cancer cachexia is directly attributable to up to 40% of cancer-related deaths. 2, 3, 4, 5 The review from Dr. Greene's group (Lim et al.) provides an overview of perspectives in cancer cachexia. While the work from Dr. Carson's group (Halle et al.) then expands on concepts in cancer cachexia to examine muscle more specifically and how exercise may serve as a countermeasure to cancer cachexia. Finally, the work from Dr. Fluckey's group (Deaver et al.) assesses the regulation of anabolism with a particular focus on mRNA translation, a critical aspect to the maintenance of skeletal muscle mass. While these reviews are united in their inspiration and in their overarching topic, each review offers a unique perspective, and together represent an exciting overview of the current literature pertaining to skeletal muscle wasting diseases. This editorial provides a brief introduction to each of these reviews.
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影响因子：
45.3
作者：
Roeland, Eric J.;Bohlke, Kari;Loprinzi, Charles L.
通讯作者：
Loprinzi, Charles L.
DOI：
10.1002/jcsm.12232
发表时间：
2017-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Brown JL;Rosa-Caldwell ME;Lee DE;Blackwell TA;Brown LA;Perry RA;Haynie WS;Hardee JP;Carson JA;Wiggs MP;Washington TA;Greene NP
通讯作者：
Greene NP
基于炎症的癌症恶病质调节。
影响因子：
--
作者：
Onesti JK;Guttridge DC
通讯作者：
Guttridge DC
DOI：
10.1002/jcsm.12201
发表时间：
2017-10
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Solheim TS;Laird BJA;Balstad TR;Stene GB;Bye A;Johns N;Pettersen CH;Fallon M;Fayers P;Fearon K;Kaasa S
通讯作者：
Kaasa S