Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles
Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles
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DOI：
10.1039/c1sc00619c
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发表时间：
2012-01-01
期刊：
影响因子：
8.4
通讯作者：
Lygin, Alexander V.
中科院分区：
文献类型：
--
作者：
Ackermann, Lutz;Wang, Lianhui;Lygin, Alexander V.
在环境空气下，使用催化量的Cu(OAc)₂·H₂O实现了钌催化的炔烃需氧氧化环化反应。C - H / N - H键的官能化反应具有独特的选择性和广泛的适用范围，可生成具有生物活性的海洋生物碱的结构类似物。
Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)(2)center dot H2O under ambient air. The C-H/N-H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloids.