Nimodipine and the Haemodynamic and Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat
Nimodipine and the Haemodynamic and Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat
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尼莫地平与大鼠大脑中动脉闭塞的血流动力学和组织病理学后果
DOI：
10.1038/jcbfm.1986.55
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发表时间：
1986
影响因子：
6.3
通讯作者：
G. Teasdale
中科院分区：
文献类型：
--
作者：
O. Gotoh;A. A. Mohamed;J. Mcculloch;D. Graham;A. Harper;G. Teasdale
研究了麻醉大鼠大脑中动脉（MCA）闭塞后5分钟开始给予尼莫地平（1 μg kg−1 min−1）对脑血流动力学（[14C]碘安替比林放射自显像）和神经病理结果（组织学缺血组织体积）的影响。测量闭塞血管的同侧或对侧共37个神经解剖学定义区域的局部CBF （LCBF）水平，并使用一种新的定量密度测量方法检查自x线摄影，该方法采用不同冠状面脑切片CBF的频率分布分析。两种分析方法均显示，在缺血事件后给予尼莫地平，并没有改变MCA闭塞后的CBF分布模式。通过组织学检查确定缺血性脑损伤程度。没有证据表明，接受尼莫地平治疗的动物的缺血损伤程度，无论是在八个不同冠状面的切片还是在总体上，都与只接受溶解药物的媒介的动物有显著不同。在MCA闭塞后开始给予尼莫地平，与在动脉闭塞前给予尼莫地平时发现的LCBF水平升高和缺血组织体积减少形成对比，发现脑循环和神经病理改变缺乏。
The effect of the administration of nimodipine (1 μg kg−1 min−1), initiated 5 min after occlusion of a middle cerebral artery (MCA), upon cerebral haemodynamics ([14C]iodoantipyrine autoradiography) and neuropathological outcome (volume of histologically ischaemic tissue) was investigated in anaesthetized rats. Measurements were made of the level of local CBF (LCBF) in a total of 37 neuroanatomically defined areas, either ipsilateral or contralateral to the occluded vessel, and the autoradiograms were examined using a new approach to quantitative densitometry that employed a frequency distribution analysis of the CBF in sections of the brain at different coronal planes. Both methods of analysis showed that nimodipine, administered after the ischaemic event, did not modify the pattern of CBF distribution after MCA occlusion. The extent of ischaemic brain damage was determined by histological examination. There was no evidence that the extent of ischaemic damage, either in sections at eight different coronal planes or in overall volume, was significantly different in animals that received nimodipine from that observed in animals that received only the vehicle used to dissolve the drug. The lack of cerebral circulatory and neuropathological alterations when nimodipine administration is initiated after occlusion of the MCA is contrasted with the higher levels of LCBF and the reductions in the volume of ischaemic tissue that were found when nimodipine was administered before occlusion of the artery.
尼莫地平对脑血流的影响。
DOI：
--
发表时间：
1983
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Haws,CW;Gourley,JK;Heistad,DD
通讯作者：
Heistad,DD