The Limiting Radius for Freezing a Tumor During Percutaneous Cryoablation
The Limiting Radius for Freezing a Tumor During Percutaneous Cryoablation
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DOI：
10.1115/1.2969759
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发表时间：
2008-11
影响因子：
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通讯作者：
A. Nakayama;Yusuke Kuwahara;Kansei Iwata;M. Kawamura
中科院分区：
文献类型：
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作者：
A. Nakayama;Yusuke Kuwahara;Kansei Iwata;M. Kawamura
在经皮冷冻治疗期间，利用生物热方程对肿瘤中的冷冻前沿进行了分析和数值追踪。研究表明，肿瘤的大小是有限度的，单个冷冻探头最多只能冷冻一次。冷冻前沿从冷冻探头径向向外移动，到达末端，从周围组织到冷冻组织的热量与被冷冻探头吸收的热量相平衡。对于使用单针冷冻探头冻结肿瘤所需的时间，分析结果和数值结果之间取得了很好的一致。为了给冷冻治疗计划提供有用的信息，我们导出了一个估算极限半径的解析表达式。
The freezing front in a tumor during percutaneous cryoablation therapy was traced both analytically and numerically exploiting a bioheat equation. It has been shown that there exists a limiting size of the tumor, which one single cryoprobe can freeze at the maximum. The freezing front moves radially outward from the cryoprobe and reaches the end, where the heat from the surrounding tissue to the frozen tissue balances with the heat being absorbed by the cryoprobe. An excellent agreement between the analytical and numerical results has been achieved for the time required to freeze the tumor using the cryoprobe of a single needle. An analytical expression for estimating the limiting radius has been derived to give useful information for cryotherapy treatment plans.