Rupture of membranes before the age of viability and birth after the age of viability: comparison of outcomes in a matched cohort study
Rupture of membranes before the age of viability and birth after the age of viability: comparison of outcomes in a matched cohort study
复制标题
DOI：
10.1038/jp.2010.11
复制
发表时间：
2010-10-01
影响因子：
2.9
通讯作者：
Shah, P. S.
中科院分区：
文献类型：
--
作者：
Soylu, H.;Jefferies, A.;Shah, P. S.
目的：比较妊娠24周前发生的足月胎膜早破（PPROM）7天婴儿的综合不良结局发生率。配对队列包括出生时无PPROM的婴儿（GA、性别和入院日期匹配）。综合不良结局评估考虑死亡或以下三种严重疾病（严重神经损伤，严重早产儿视网膜病变或慢性肺部疾病）中的任何一种。结果：29例患儿的平均疾病严重程度评分高于74例匹配的婴儿。ROM的平均持续时间分别为45 vs 2天，ROM的平均GA分别为21 vs 27周。Logistic回归证实病例的复合不良结局率风险显著较高（69 vs 47%; P = 0.02，校正比值比4.0，95%CI 1.2，13.6）。
Objective: To compare composite adverse outcome rate of infants 7 days of PPROM that occurred before 24 weeks. Matched cohort consisted of infants born without PPROM (matched for GA, sex and admission date). Composite adverse outcome was assessed considering death or any of the following three severe morbidities (severe neurological injury, severe retinopathy of prematurity or chronic lung disease).Result: The 29 cases had higher mean severity of illness score compared with 74 matched infants. Mean duration of ROM was 45 vs 2 days and mean GA at the ROM was 21 vs 27 weeks, respectively. Logistic regression confirmed significantly higher risk of composite adverse outcome rates for cases (69 vs 47%; P = 0.02, adjusted odds ratio 4.0, 95% CI 1.2, 13.6).Conclusion: The survival rate for infants born at