Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling
Nuclear import of the homeodomain protein Extradenticle in response to Wg and Dpp signalling
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DOI：
10.1038/383630a0
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发表时间：
1996-10-17
期刊：
影响因子：
64.8
通讯作者：
AbuShaar, M
中科院分区：
文献类型：
--
作者：
Mann, RS;AbuShaar, M
在果蝇中，Decapentaplegic（Dpp）（1）和Wingless（Wg）（2）分别是转化生长因子（TGF）-β和Wnt家族的两种分泌信号蛋白。虽然两者在发育过程中都是必需的，但只有少数这些信号通路的下游成分被描述。在这里，我们提出的证据表明，在胚胎中肠的两个信号通路控制的同源结构域蛋白编码的外齿（exd）基因的亚细胞定位。Exd蛋白主要是在靠近内脏中胚层的Dpp和Wg分泌细胞的内胚层细胞的核中，但在更远的内胚层细胞的细胞质中。内胚层中Exd的核定位需要dpp和log。
IN Drosophila, Decapentaplegic (Dpp)(1) and Wingless (Wg)(2) are two secreted signalling proteins of the transforming growth factor (TGF)-beta and Wnt families, respectively. Although both are often required during development, only a few downstream components of these signalling pathways have been described. Here we present evidence that in the embryonic midgut both signalling pathways control the subcellular localization of the homeodomain protein encoded by the extradenticle (exd) gene. Exd protein is predominantly nuclear in endoderm cells close to Dpp- and Wg-secreting cells of the, visceral mesoderm, but is in the cytoplasm in more distant endoderm cells. Both dpp and log are required for the nuclear localization of Exd in the endoderm.