Convection-enhanced delivery of liposomal doxorubicin in intracranial brain tumor xenografts
Convection-enhanced delivery of liposomal doxorubicin in intracranial brain tumor xenografts
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颅内脑肿瘤异种移植物中脂质体阿霉素的对流增强递送
DOI：
10.1007/s11523-006-0011-8
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发表时间：
2006
影响因子：
5.4
通讯作者：
K. Bankiewicz
中科院分区：
文献类型：
--
作者：
Y. Yamashita;R. Saito;M. Krauze;T. Kawaguchi;C. Noble;D. Drummond;D. Kirpotin;John W. Park;M. Berger;K. Bankiewicz
我们之前报道了脂质体对流增强递送（CED）进入脑组织和颅内脑肿瘤异种移植物产生强大的组织分布，可以通过磁共振成像检测。考虑到图像引导的治疗性脂质体CED是治疗脑肿瘤的一种有前景的策略，我们在动物模型中评估了聚乙二醇化脂质体多柔比星通过CED递送的疗效。在U251MG人胶质母细胞瘤颅内异种移植模型中评估了CED后聚乙二醇化脂质体阿霉素的分布、毒性和疗效。聚乙二醇化阿霉素脂质体的CED在脑肿瘤组织及周围正常脑组织中分布良好。聚乙二醇脂质体的分布不受阿霉素颗粒浓度的影响，但浓度越高，组织毒性越强。在正常大鼠脑无毒剂量（0.1 mg/ml阿霉素）下，聚乙二醇化阿霉素脂质体的CED比在最大耐受剂量下全身给药更有效。与相同剂量的游离阿霉素相比，聚乙二醇化脂质体阿霉素的CED可提高生存率。本研究的结果表明，脂质体药物的CED是治疗胶质母细胞瘤的一种很有前途的方法。
We previously reported that convection-enhanced delivery (CED) of liposomes into brain tissue and intracranial brain tumor xenografts produced robust tissue distribution that can be detected by magnetic resonance imaging. Considering image-guided CED of therapeutic liposomes as a promising strategy for the treatment of brain tumors, we evaluated the efficacy of pegylated liposomal doxorubicin delivered by CED in an animal model. Distribution, toxicity, and efficacy of pegylated liposomal doxorubicin after CED were evaluated in a U251MG human glioblastoma intracranial xenograft model. CED of pegylated liposomal doxorubicin achieved good distribution in brain tumor tissue and surrounding normal brain tissue. Distribution was not affected by the particle concentration of pegylated liposomal doxorubicin, but tissue toxicity increased at higher concentrations. CED of pegylated liposomal doxorubicin, at a dose not toxic to normal rat brain (0.1 mg/ml doxorubicin), was significantly more efficacious than systemic administration of pegylated liposomal doxorubicin at the maximum tolerated dose. CED of pegylated liposomal doxorubicin resulted in improved survival compared to CED of free doxorubicin at the same dose. Outcomes of this study suggest that CED of liposomal drugs is a promising approach for the treatment of glioblastoma.
在大鼠神经胶质瘤模型中通过脑内裂解递送托泊替康的组织分布和抗肿瘤活性。
影响因子：
4.8
作者：
M. Kaiser;A. Parsa;R. Fine;Jonathan S. Hall;I. Chakrabarti;J. Bruce
通讯作者：
J. Bruce
影响因子：
4.1
作者：
Degen, JW;Walbridge, S;Lonser, RR
通讯作者：
Lonser, RR
影响因子：
2
作者：
A. Kolchinsky;Roninson Ib
通讯作者：
A. Kolchinsky;Roninson Ib