Homogeneity Index: An objective tool for assessment of conformal radiation treatments.
Homogeneity Index: An objective tool for assessment of conformal radiation treatments.
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DOI：
10.4103/0971-6203.103606
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发表时间：
2012-10
影响因子：
0.9
通讯作者：
Bisht SS
中科院分区：
文献类型：
--
作者：
Kataria T;Sharma K;Subramani V;Karrthick KP;Bisht SS
均匀性指数（HI）是分析靶体积内剂量分布均匀性的客观工具。文献中描述了各种计算公式，但关于理想公式和影响该指数的因素的数据很少。本研究旨在使用各种公式分析患者的 HI，并找出 HI 与处方剂量、靶体积和靶位置之间的相关性。对 99 名患者进行了回顾性审查。 HI 使用五个不同的公式 (A-E) 计算。根据处方剂量、靶体积和靶位置将患者分为五组，分析每组的平均 HI，以找出这些因素与 HI 之间的相关性。当存在多个目标体积时，研究主要目标体积。使用SPSS 16.0版本进行统计计算。 99 名患者被发现可评估，其中 75 名男性和 24 名女性。九十五名患者接受了激进治疗，四名患者接受了姑息治疗。治疗部位为头颈部（46.4%）、骨盆（17.1%）、大脑（15.1%）、腹部（12.1%）和胸部（6.1%）。平均处方剂量为 4304 cGy（厘格雷），平均靶体积为 476.2 cc。不同公式的HI平均值分别为1.21、2.08、30.13、21.51和1.27。使用各种公式特别是考虑处方剂量（C、D）的公式计算的 HI 之间存在相当大的一致性。统计分析显示，目标位置和体积之间不存在显着相关性，但随着处方剂量的增加，HI 有改善的趋势。未来对更多患者的研究可以证实我们的结果。
Homogeneity Index (HI) is an objective tool to analyz the uniformity of dose distribution in the target volume. Various formulae have been described in literature for its calculation but there is paucity of data regarding the ideal formula and the factors affecting this index. This study was undertaken to analyze HI in our patients using various formulae and to find out the co-relation between HI and prescribed dose, target volume and target location. A retrospective review of 99 patients was performed. HI was calculated using five different formulae (A-E). The patients were divided in five groups each, based on prescribed dose, target volume and target location and mean HI of each group was analysed to find the co-relation between these factors and HI. When there were multiple target volumes the primary target volume was studied. The statistical calculation was done using SPSS version 16.0. Ninety nine patients were found evaluable with 75 males and 24 females. Ninety five patients were treated with radical intent and four with palliative intent. The sites treated were head and neck (46.4%), Pelvis (17.1%), brain (15.1%), abdomen (12.1%), and thorax (6.1%). The mean prescribed dose was 4304 cGy (centiGray) and the mean target volume was 476.2 cc. The mean value of HI was 1.21, 2.08, 30.13, 21.51 and 1.27 with different formulae. There was considerable agreement between HI calculated using various formulae specially the formulae considering prescribed dose (C, D). On statistical analysis, there was no significant co-relation between the location and volume of target but there was a trend toward better HI with increasing prescribed dose. Future studies with more number of patients can confirm our results.