Catechol‐Based Molecular Memory Film for Redox Linked Bioelectronics
Catechol‐Based Molecular Memory Film for Redox Linked Bioelectronics
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DOI：
10.1002/aelm.202000452
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发表时间：
2020-07
影响因子：
6.2
通讯作者：
Si Wu;Eunkyoung Kim;Chen‐yu Chen;Jinyang Li;Eric VanArsdale;Christopher Grieco;B. Kohler;W. Bentley;Xiaowen Shi;G. Payne
中科院分区：
文献类型：
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作者：
Si Wu;Eunkyoung Kim;Chen‐yu Chen;Jinyang Li;Eric VanArsdale;Christopher Grieco;B. Kohler;W. Bentley;Xiaowen Shi;G. Payne
Redox正在成为生物设备通信的替代模式。与更熟悉的离子电模式相反：（i）氧化还原涉及通过氧化还原反应的电子流动;（ii）水性介质是这种电子流动的"绝缘体"，因为自由电子通常不存在于水中;和（iii）氧化还原状态本质上是数字的（氧化和还原）。通过利用这些独特的功能，儿茶酚基分子记忆膜的报告。这种存储器是通过电化学接枝儿茶酚到壳聚糖-琼脂糖多糖网络，以产生氧化还原活性但不导电的基质。接枝的儿茶酚部分的氧化还原状态用作2态记忆。结果表明，这些氧化还原状态：可以重复切换的扩散介质（电子梭）;可以很容易地读取电或光学;是稳定的至少2小时，在没有能量的情况下;是敏感的生物相关的氧化和还原上下文;和可以切换酶。这种基于邻苯二酚的分子记忆膜是用于氧化还原连接生物电子学的简单电路元件。
Redox is emerging as an alternative modality for bio‐device communication. In contrast to the more familiar ionic electrical modality: (i) redox involves the flow of electrons through oxidation–reduction reactions; (ii) the aqueous medium is an “insulator” to this electron flow since free electrons do not normally exist in water; and (iii) redox states are intrinsically digital (oxidized and reduced). By exploiting these unique features, a catechol‐based molecular memory film is reported. This memory is fabricated by electrochemically grafting catechol to a chitosan–agarose polysaccharide network to generate a redox‐active but non‐conducting matrix. The redox state of the grafted catechol moieties serves as the 2‐state memory. It is shown that these redox states: can be repeatedly switched by diffusible mediators (electron shuttles); can be easily read electrically or optically; are stable for at least 2 h in the absence of energy; are sensitive to biologically relevant oxidizing and reducing contexts; and can be switched enzymatically. This catechol‐based molecular memory film is a simple circuit element for redox linked bioelectronics.