Lateral Thalamic Infarction and the Vascular Geometry of the Posterior Cerebral Artery
Lateral Thalamic Infarction and the Vascular Geometry of the Posterior Cerebral Artery
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DOI：
10.1159/000439062
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发表时间：
2016-01-01
影响因子：
2.9
通讯作者：
Kim, Jong S.
中科院分区：
文献类型：
--
作者：
Kim, Bum Joon;Kim, Seung Min;Kim, Jong S.
背景：载瘤动脉的几何特性影响局部动脉粥样硬化和穿支动脉梗死的发展。在这项研究中，我们的目的是调查大脑后动脉（PCA）的血管几何形状和孤立性外侧丘脑梗死（LTI），最常见的丘脑梗死类型的发展之间的关联。研究方法：评估LTI患者相应PCA的几何特性，包括远端基底动脉（BA）和近端PCA的直径、远端BA - PCA角度、第一PCA角度（P1和P2之间的角度）以及后交通动脉（Pcom）的存在。这些参数从同病灶PCA得到的contralesional PCA和相应的PCA在年龄和性别匹配的对照进行了比较。结果：45例LTI患者入组。与对照组受试者相比，LTI患者的同病灶PCA显示出更大的同病灶P1 - P2角（分别为81.4 +/- 22.6 vs. 71.3 +/- 23.2度; p = 0.04）和更高的Pcom患病率（42.2 vs. 13.3%; p = 0.002）。与对侧PCA相比，同侧PCA的直径更小，P1和P2节段之间的夹角更大，Pcom的患病率更高。高脂血症（OR 3.548（1.283-9.811）; p = 0.02）和Pcom（OR 3.507（1.104-11.135）; p = 0.03）是与LTI独立相关的因素。结论：P1 - P2角和Pcom的存在可能影响PCA的局部血流动力学，这与LTI的发展有关。(C)2015 S. Karger AG，巴塞尔
Background: The geometric properties of the parental artery affect the development of local atherosclerosis and perforator infarction. In this study, we aimed at investigating the association between vascular geometry of the posterior cerebral artery (PCA) and the development of isolated lateral thalamic infarction (LTI), the most frequent type of thalamic infarction. Methods: The geometric properties of the corresponding PCA in LTI patients were assessed and they include the diameters of the distal basilar artery (BA) and proximal PCA, distal BA - PCA angle, first PCA angle (angle between P1 and P2), and the presence of the posterior communicating artery (Pcom). These parameters obtained from the ipsilesional PCA were compared with the contralesional PCA and the corresponding PCA in age-and sex-matched controls. Results: Forty-five LTI patients were enrolled. The ipsilesional PCA in LTI patients demonstrated a greater ipsilesional P1 - P2 angle (81.4 +/- 22.6 vs. 71.3 +/- 23.2 degrees, respectively; p = 0.04) and a higher prevalence of Pcom (42.2 vs. 13.3%; p = 0.002) when compared to control subjects. In comparison with the contralesional PCA, ipsilesional PCA demonstrated a smaller diameter, larger angle between P1 and P2 segment, and a higher prevalence of Pcom. The presence of hyperlipidemia (OR 3.548 (1.283-9.811); p = 0.02) and Pcom (OR 3.507 (1.104-11.135); p = 0.03) was a factor that was independently associated with LTI. Conclusions: Local hemodynamics in the PCA may be influenced by the P1 - P2 angle and the presence of Pcom, which are associated with the development of LTI. (C) 2015 S. Karger AG, Basel