One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms
One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms
复制标题
一碳代谢通过表观遗传机制将营养摄入与胚胎发育联系起来
DOI：
10.1155/2019/3894101
复制
发表时间：
2019
影响因子：
4.3
通讯作者：
Yachuan Zhou
中科院分区：
文献类型：
--
作者：
Si Wu;Jun Zhang;Feifei Li;Wei Du;Xin Zhou;Mian Wan;Yi Fan;Xin Xu;Xuedong Zhou;Liwei Zheng;Yachuan Zhou
除了能量产生，营养代谢在干细胞谱系确定中起着至关重要的作用。基于营养可用性和饮食习惯的代谢变化影响干细胞身份。有证据表明，在胚胎发育和后代后期生活中发生的代谢和表观遗传机制之间存在密切联系。代谢调节表观遗传机制，如DNA，组蛋白和microRNA的修饰。反过来，这些表观遗传机制调节代谢途径以改变代谢组。一碳代谢（OCM）是一个重要的代谢过程，涉及甲基的转移，导致多种细胞活动的调节。OCM循环及其相关的微量营养素普遍存在于干细胞中，并参与表观遗传机制。本文简要介绍了OCM的过程和所涉及的微量营养素，并讨论了OCM相关的表观遗传修饰，包括DNA甲基化、组蛋白修饰和microRNA。我们进一步考虑了潜在的OCM介导的营养和胚胎发育中的表观遗传修饰之间的联系。
Beyond energy production, nutrient metabolism plays a crucial role in stem cell lineage determination. Changes in metabolism based on nutrient availability and dietary habits impact stem cell identity. Evidence suggests a strong link between metabolism and epigenetic mechanisms occurring during embryonic development and later life of offspring. Metabolism regulates epigenetic mechanisms such as modifications of DNA, histones, and microRNAs. In turn, these epigenetic mechanisms regulate metabolic pathways to modify the metabolome. One-carbon metabolism (OCM) is a crucial metabolic process involving transfer of the methyl groups leading to regulation of multiple cellular activities. OCM cycles and its related micronutrients are ubiquitously present in stem cells and feed into the epigenetic mechanisms. In this review, we briefly introduce the OCM process and involved micronutrients and discuss OCM-associated epigenetic modifications, including DNA methylation, histone modification, and microRNAs. We further consider the underlying OCM-mediated link between nutrition and epigenetic modifications in embryonic development.