Gastric cancer prevention by demethylation.
Gastric cancer prevention by demethylation.
复制标题
DOI：
10.1158/1940-6207.capr-13-0067
复制
发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Peek RM Jr
中科院分区：
文献类型：
--
作者：
Schneider BG;Peek RM Jr
Niwa等在本期中报道，在幽门螺杆菌促进的胃癌动物模型中，使用DNA去甲基化剂5-氮杂-2 ′-脱氧胞苷治疗可降低胃癌的发病率。这项具有挑衅性的研究强调了DNA甲基化变化的重要性，这些变化有助于炎症相关癌症的起源。这些发现还提高了通过在肿瘤发生早期改变DNA甲基化事件来预防癌症的可能性。
Niwa et al. report in this issue that treatment with the DNA demethylation agent 5-aza-2′-deoxycytidine decreases the incidence of gastric cancers in an animal model of Helicobacter pylori-promoted gastric cancer. This provocative study underscores the importance of changes in DNA methylation that contribute to the origin of inflammation-related cancers. The findings also raise the exciting possibility of cancer prevention by altering DNA methylation events early during tumorigenesis.