Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure.
Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure.
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DOI：
10.3390/biomedicines10050981
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发表时间：
2022-04-23
期刊：
影响因子：
4.7
通讯作者：
Felder RA
中科院分区：
文献类型：
--
作者：
Xu P;Sudarikova AV;Ilatovskaya DV;Gildea JJ;Akhter M;Carey RM;Yue W;Jose PA;Felder RA
血压盐敏感性（BP）是指饮食盐摄入量增加后血压升高，这与心血管疾病发病率增加和早期死亡有关。然而，钠摄入量的减少也会增加死亡率和发病率。逆盐敏感性（ISS），定义为低盐饮食时血压的反常升高，约占人口的11%，可能是造成这种现象的原因。上皮钠通道（ENaC）是肾脏钠重吸收的主要调节因子。在这项研究中，从表型盐研究参与者的尿液中培养人肾小管上皮细胞（hRTC）。ISS细胞中αENaC的表达量明显低于耐盐hRTC，而膜片钳法分析胰蛋白酶处理后ISS细胞中enac样通道活性显著升高。ISS细胞αENaC的表达在高盐处理下降低，醛固酮处理下升高。此外，αENaC变异rs4764586在ISS中更为普遍。综上所述，αENaC可能与低盐组ISS高血压相关。这些发现可能有助于理解ISS和低盐效应对发病率和死亡率的影响机制。
Salt sensitivity of blood pressure (BP) refers to an increase in BP following an increase in dietary salt, which is associated with increased incidence of cardiovascular disease and early death. However, decreased sodium intake also increases mortality and morbidity. Inverse salt sensitivity (ISS), defined as a paradoxical increase in BP on a low-salt diet, about 11% of the population, may be the cause of this phenomenon. The epithelial sodium channel (ENaC) is a major regulator of sodium reabsorption in the kidney. In this study, human renal tubular epithelial cells (hRTC) were cultured from the urine of phenotyped salt study participants. αENaC expression was significantly lower in ISS than salt resistant (SR) hRTC, while ENaC-like channel activity was dramatically increased by trypsin treatment in ISS cells analyzed by patch clamp. αENaC expression was also decreased under high-salt treatment and increased by aldosterone treatment in ISS cells. Moreover, the αENaC variant, rs4764586, was more prevalent in ISS. In summary, αENaC may be associated with ISS hypertension on low salt. These findings may contribute to understanding the mechanisms of ISS and low salt effect on morbidity and mortality.
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影响因子：
4
作者：
Baldin, Jan-Peter;Barth, Daniel;Fronius, Martin
通讯作者：
Fronius, Martin
影响因子：
5.5
作者：
Diakov, Alexei;Bera, Katarzyna;Korbmacher, Christoph
通讯作者：
Korbmacher, Christoph
DOI：
10.1161/hypertensionaha.110.152256
发表时间：
2010-09
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Gildea JJ;Shah I;Weiss R;Casscells ND;McGrath HE;Zhang J;Jones JE;Felder RA
通讯作者：
Felder RA
影响因子：
3.2
作者：
Felder RA;White MJ;Williams SM;Jose PA
通讯作者：
Jose PA
影响因子：
6.1
作者：
Dörrenhaus, A;Müller, JIF;Föllmann, W
通讯作者：
Föllmann, W