Early detection of gastric cancer beyond endoscopy- new methods
Early detection of gastric cancer beyond endoscopy- new methods
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DOI：
10.1016/j.bpg.2021.101731
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发表时间：
2021-05-08
影响因子：
3.2
通讯作者：
Line, Aija
中科院分区：
文献类型：
--
作者：
Leja, Marcis;Line, Aija
胃癌的早期检测仍然是一个挑战。本文综述了非侵入性检测方法的研究现状。传统的肿瘤标志物如CEA、CA72-4、CA19-9、CA15-3和CA12-5的作用主要集中在治疗监测上，而不是早期检测。基于对癌症特异性甲基化模式(PanSeer)、循环蛋白和循环肿瘤DNA突变(CancerSEEK)以及miRNA面板的检测的测试已经显示出令人振奋的结果，使这些更接近实践。在基于循环肿瘤细胞、细胞外小泡和无细胞RNA检测的测试达到实用之前，还需要更广泛的研究。检测人类呼吸中的挥发性有机化合物是一个很有前途的发展；用于这一目的的传感器技术在筛查环境中可能非常有吸引力。(C)2021年爱思唯尔有限公司。保留所有权利。
Early detection of gastric cancer is remaining a challenge. This review summarizes current knowledge on non-invasive methods that could be used for the purpose.The role of traditional cancer markers such as CEA, CA 72-4, CA 19-9, CA 15-3, and CA 12-5 lies mainly in therapy monitoring than early detection.Most extensive studied biomarkers (pepsinogens, ABC method) are aiming at the detection of pre cancerous lesions with modest sensitivity for cancer. Tests based on the detection of cancer-specific methylation patterns (PanSeer), circulating proteins and mutations in circulating tumour DNA (CancerSEEK), as well as miRNA panels have demonstrated promising results bringing those closer to practice. More extensive research is required before tests based on the detection of circulating tumour cells, extracellular vesicles and cell-free RNA could reach the practice.Detection of volatile organic compounds in the human breath is a promising development; sensor technologies for this purpose could be very attractive in screening settings. (c) 2021 Elsevier Ltd. All rights reserved.