Analysis of cytosolic phosphoethanolamine and ethanolamine and their correlation with prognostic factors in breast cancer.
Analysis of cytosolic phosphoethanolamine and ethanolamine and their correlation with prognostic factors in breast cancer.
复制标题
乳腺癌细胞质磷酸乙醇胺和乙醇胺分析及其与预后因素的相关性。
DOI：
10.1111/j.1349-7006.1991.tb02709.x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kasai,H
中科院分区：
文献类型：
--
作者：
Kano-Sueoka,T;Watanabe,T;Miya,T;Kasai,H
准确的预后因素对于做出癌症治疗决策至关重要。我们测定了53例乳腺癌患者肿瘤组织中磷酸乙醇胺和乙醇胺的胞浆含量，试图探讨这些胺作为预后指标的可能性。采用高效液相色谱法测定磷酸乙醇胺和乙醇胺的含量。这些胺或氨基酸的摩尔量与作为单峰洗脱的丙氨酸加酪氨酸的摩尔量之比用于分析和比较不同肿瘤样品的结果。结果表明，磷酸乙醇胺或乙醇胺的值变化显着大于氨基酸的值，例如甘氨酸加苏氨酸或谷氨酰胺加丝氨酸（这些氨基酸分别作为单峰洗脱）。分析了磷酸乙醇胺、乙醇胺和磷酸乙醇胺加乙醇胺的值与几种常用的乳腺疾病预后因素的关系。结果表明，具有较高有丝分裂指数的组比具有较低有丝分裂指数的组具有显着更高的磷酸乙醇胺或磷酸乙醇胺加乙醇胺的值。随着疾病阶段的增加，磷酸乙醇胺加乙醇胺的值似乎也变得更高。然而，在涉及的腋窝淋巴结方面，类固醇激素受体阳性组和阴性组之间或阳性组和阴性组之间没有观察到相关性。因此，细胞质中磷酸乙醇胺或磷酸乙醇胺加乙醇胺的含量似乎与一些预后指标相关。
Availability of accurate prognostic factors is vital in making decisions on cancer therapy. We have measured the cytosolic contents of phosphoethanolamine and ethanolamine in tumor tissues of 53 breast cancer patients in an attempt to explore the possibility that these amines could be used as prognostic indicators. The levels of phosphoethanolamine and ethanolamine were determined by high‐performance liquid chromatography. The ratios of the molar quantity of these amines or amino acids to that of alanine plus tyrosine, which eluted as a single peak, were used to analyze and compare the results among different tumor samples. The results indicated that the values for phosphoethanolamine or ethanolamine varied significantly more than the values for amino acids, such as glycine plus threonine or glutamine plus serine (these amino acids were eluted as single peaks, respectively). The values for phosphoethanolamine, ethanolamine, and phosphoethanolamine plus ethanolamine were analyzed in relation to several commonly used prognostic factors of breast disease. The results indicated that groups having higher mitotic indices had significantly higher values for phosphoethanolamine or phosphoethanolamine plus ethanolamine than the group having lower mitotic indices. As the stage of the disease increased, the values for phosphoethanolamine plus ethanolamine also seemed to become higher. No correlation, however, was observed between steroid hormone receptor positive and negative groups or between positive and negative groups with regard to involved axillary lymph nodes. The content of phosphoethanolamine or phosphoethanolamine plus ethanolamine in cytosol therefore seems to be correlated with some prognostic indicators.