Regulation of pulmonary inflammation by mesenchymal cells
Regulation of pulmonary inflammation by mesenchymal cells
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DOI：
10.1016/j.pupt.2014.03.001
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发表时间：
2014-12-01
影响因子：
3.2
通讯作者：
Schuliga, Michael
中科院分区：
文献类型：
--
作者：
Alkhouri, Hatem;Poppinga, Wilfred Jelco;Schuliga, Michael
肺部炎症和组织重塑是慢性呼吸道疾病如哮喘、慢性阻塞性肺病（COPD）、特发性肺纤维化（IPF）和肺动脉高压（PH）的常见因素。在疾病中，肺间充质细胞不仅有助于组织重塑，而且在肺部炎症中也具有重要作用。本文就肺间充质细胞如气道平滑肌细胞和肺成纤维细胞在慢性呼吸道疾病中的免疫调节功能作一综述。该综述的一个重要主题是，肺间充质细胞不仅对炎症介质做出反应，而且还产生自己的介质，无论是促炎介质还是促消退介质，其影响肺免疫应答的数量和质量。还讨论了这些细胞中有缺陷的促炎或促消退信号传导可能有助于疾病进展的概念。最后，专门针对肺间充质细胞的免疫调节功能，以提高慢性呼吸道疾病的治疗控制的概念被认为是。(C)2014爱思唯尔有限公司版权所有。
Pulmonary inflammation and tissue remodelling are common elements of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension (PH). In disease, pulmonary mesenchymal cells not only contribute to tissue remodelling, but also have an important role in pulmonary inflammation. This review will describe the immunomodulatory functions of pulmonary mesenchymal cells, such as airway smooth muscle (ASM) cells and lung fibroblasts, in chronic respiratory disease. An important theme of the review is that pulmonary mesenchymal cells not only respond to inflammatory mediators, but also produce their own mediators, whether pro-inflammatory or pro-resolving, which influence the quantity and quality of the lung immune response. The notion that defective pro-inflammatory or pro-resolving signalling in these cells potentially contributes to disease progression is also discussed. Finally, the concept of specifically targeting pulmonary mesenchymal cell immunomodulatory function to improve therapeutic control of chronic respiratory disease is considered. (C) 2014 Elsevier Ltd. All rights reserved.