Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication
Extracorporeal Shock Wave Therapy Improves the Walking Ability of Patients With Peripheral Artery Disease and Intermittent Claudication
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DOI：
10.1253/circj.cj-11-1216
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发表时间：
2012-06-01
影响因子：
3.3
通讯作者：
Satomi, Susumu
中科院分区：
文献类型：
--
作者：
Serizawa, Fukashi;Ito, Kenta;Satomi, Susumu
背景资料：尽管最近在外周动脉疾病（PAD）的旁路手术和导管介入治疗方面取得了进展，但膝下病变的血运重建治疗的长期结果仍然不令人满意。我们以前已经证明，低能量体外冲击波（SW）治疗有效地诱导新血管形成，通过上调血管生成因子和改善猪和人的心肌缺血和兔后肢缺血。因此，在这项研究中，我们研究了我们的SW疗法是否也提高了步行能力的患者PAD和间歇性claudiation.Methods和结果：我们治疗了12例患者（19肢）在方丹II期（男/女，10/2; 60-86岁）与低能量SW治疗他们的缺血小腿肌肉3次/周，连续3周。24周后，行走障碍问卷的疼痛和距离子量表评分显著改善（分别为33 +/- 25 vs. 64 +/- 26，27 +/- 16 vs. 64 +/- 23，均P
Background: Despite the recent advances in bypass surgery and catheter interventional therapy for peripheral artery disease (PAD), the long-term outcome of revascularization therapy for infrapopliteal lesions remains unsatisfactory. We have previously demonstrated that low-energy extracorporeal shock wave (SW) therapy effectively induces neovascularization through upregulation of angiogenic factors and improves myocardial ischemia in pigs and humans and in hindlimb ischemia in rabbits. In this study, we thus examined whether our SW therapy also improves the walking ability of patients with PAD and intermittent claudication.Methods and Results: We treated 12 patients (19 limbs) in Fontaine II stage (males/females, 10/2; 60-86 years old) with low-energy SW therapy to their ischemic calf muscle 3 times/week for 3 consecutive weeks. After 24 weeks, the pain and distance subscale scores of the walking impairment questionnaire were significantly improved (33 +/- 25 vs. 64 +/- 26, 27 +/- 16 vs. 64 +/- 23, respectively, both P