THE EFFECT OF OXYGEN BREATHING AND RADIOTHERAPY UPON THE TISSUE OXYGEN TENSION OF SOME HUMAN TUMOURS
THE EFFECT OF OXYGEN BREATHING AND RADIOTHERAPY UPON THE TISSUE OXYGEN TENSION OF SOME HUMAN TUMOURS
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DOI：
10.1259/0007-1285-36-426-418
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发表时间：
1963-01-01
影响因子：
2.6
通讯作者：
NAYLOR, PFD
中科院分区：
文献类型：
--
作者：
EVANS, NTS;NAYLOR, PFD
对正在接受高压氧放射治疗的人体肿瘤的组织氧分压进行了测量。使用脉冲电压、膜覆盖电极系统进行极谱测量。这些电极每17秒测量一次直径为200亩的圆形区域内的平均氧分压。当患者呼吸空气时，他们肿瘤中记录的平均氧分压显示出非常大的散布。在所研究的1例S肿瘤中，张力值从0到100毫米汞不等。在一个大气层中100%呼吸氧气，通常但不总是会增加氧气的张力。在四个大气层中100%呼吸氧气会增加所有被研究的肿瘤部位的氧分压。照射后，在一个大气层中呼吸空气和100%氧气时，肿瘤氧分压均增加。然而，在5%的水平上，这一增长几乎没有显著意义。肿瘤与氧气的饱和速度通常比正常皮肤慢。放疗后无全身性改变。测量肿瘤中一个部位的氧分压不能提供有关其他部位的氧分压的信息。这强调了肿瘤中血管模式的不均质性。
Measurements of tissue oxygen tension have been made in human tumours which were being treated by high pressure oxygen radiotherapy. The measurements were made polarographically using a pulsed-voltage, membrane-covered electrode system. The electrodes measure mean oxygen tension over a circular area of 200 [mu] in diameter every 17 seconds. While the patients were breathing air the mean oxygen tensions recorded in their tumours showed a very large scatter. In one patient''s tumour which was studied the tension varied from 0 to 100 mm Hg. Breathing 100 per cent oxygen at one atmosphere usually but not always produced an increase in oxygen tension. Breathing 100 per cent oxygen at four atmospheres produced an increase in oxygen tension in all of the tumour sites which were studied. Following irradiation there was an increase in tumour oxygen tension both while breathing air and 100 per cent oxygen at one atmosphere. The increase was, however, barely significant at the 5 per cent level. The rate of saturation of the tumours with oxygen was often slower than in normal skin. There was no systematic change following radiotherapy. Measurements of oxygen tension at one site in a tumour give no information concerning the oxygen tension at other sites. This emphasises the lack of homogeneity of the vascular pattern in tumours.