Effects of pregnancy and labor on oxytocin levels in human plasma and cerebrospinal fluid.
Effects of pregnancy and labor on oxytocin levels in human plasma and cerebrospinal fluid.
复制标题
妊娠和分娩对人血浆和脑脊液中催产素水平的影响。
DOI：
10.1507/endocrj1954.32.875
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Mizuno
中科院分区：
文献类型：
--
作者：
S. Takeda;Y. Kuwabara;M. Mizuno
为探讨催产素在妊娠和分娩中的意义，采用放射免疫分析法测定了孕妇血浆和脑脊液中催产素的浓度。从23名孕妇（11名临产前，12名临产中），15名非孕妇和4名男性的脊髓穿刺麻醉中获得血浆和CSF样品。在男性和非孕妇，CSF催产素水平显着高于血浆水平。妊娠患者临产前或临产时血浆中的水平显著高于非妊娠患者。未分娩孕妇和分娩前孕妇的CSF水平（平均值± SE，9.7 ± 1.5 μ u/ml）无显著差异（10.1 ± 1.2 μ u/ml），但分娩孕妇的CSF水平（18.6 ± 2.3 μ m/ml）显著高于分娩前孕妇。这些结果有力地表明，人血浆和CSF中的催产素水平是由不同的机制控制的，并且增加的催产素可能具有某些特定的中枢作用。
In order to investigate the significance of oxytocin in pregnancy and labor, oxytocin concentrations in plasma and cerebrospinal fluid (CSF) were determined using the specific radioimmunoassay. Plasma and CSF samples were obtained from 23 pregnant women (11 pre labor, 12 in labor), 15 nonpregnant women and 4 men at spinal puncture for anesthesia. In males and nongravidas, CSF levels of oxytocin were significantly higher than plasma levels. Plasma levels in pregnant patients pre or in labor were significantly higher than those in nongravidas. No significant difference between CSF levels in prelabor gravidas (mean +/- SE, 9.7 +/- 1.5 mu u/ml) and nongravidas (10.1 +/- 1.2 mu u/ml) was found. However, CSF levels in gravidas in labor (18.6 +/- 2.3 micromicrons/ml were significantly higher than the levels in prelabor gravidas. These results strongly suggest that oxytocin levels in human plasma and CSF are controlled by different mechanisms and that the increased oxytocin could have some specific central actions.