HEALING OF CANCELLOUS BONE OSTEOTOMY IN RABBITS .1. REGULATION OF BONE VOLUME AND THE REGIONAL ACCELERATORY PHENOMENON IN NORMAL BONE
HEALING OF CANCELLOUS BONE OSTEOTOMY IN RABBITS .1. REGULATION OF BONE VOLUME AND THE REGIONAL ACCELERATORY PHENOMENON IN NORMAL BONE
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DOI：
10.1002/jor.1100110216
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发表时间：
1993-03-01
影响因子：
2.8
通讯作者：
PERREN, S
中科院分区：
文献类型：
--
作者：
BOGOCH, E;GSCHWEND, N;PERREN, S
我们对成熟的新西兰大白兔进行了简单、不移位、不完全的内髁远端截骨术，并允许无固定治疗4周。恢复期在饮水中加入骨标钙黄蛋白。从地面染色和未染色的切片中，我们确定了五个区域的组织形态学参数：截骨间隙、截骨旁、外侧髁、干骺端和骨干。4周时，新形成的松质骨覆盖了截骨间隙。截骨术也刺激了截骨周围内侧髁松质骨的新骨形成。在那个部位，我们发现新骨增加了五倍，而骨体积（BV）没有变化。未手术的外侧髁松质骨或干骺端或骨干皮质骨未观察到骨形成的刺激。尽管截骨股骨内侧髁的新骨形成增加，但BV的维持可能是由于局部骨重塑加速。
We performed a simple, undisplaced, incomplete osteotomy of the distal medial condyle of mature New Zealand White rabbits and permitted healing without fixation for 4 weeks. During the recovery period, the rabbits received the bone label calcein in their drinking water. From ground stained and unstained sections, we determined histomorphometric parameters in five zones: osteotomy gap, juxtaosteotomy, lateral condyle, metaphysis, and diaphysis. At 4 weeks, newly formed cancellous bone had obliterated the osteotomy gap. Osteotomy also stimulated new bone formation in cancellous bone of the medial condyle around the osteotomy. At that site, we found a fivefold increase in new bone without a change in bone volume (BV). Stimulation of bone formation was not observed in cancellous bone of the lateral condyle that had not been operated on or in cortical bone of the metaphysis or diaphysis. The maintenance of BV, despite increased new bone formation in the osteotomized medial femoral condyle, was probably due to a local acceleration of bone remodeling.