TRANSPLANTATION IMMUNITY IN BONE HOMOGRAFTING
TRANSPLANTATION IMMUNITY IN BONE HOMOGRAFTING
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DOI：
10.1302/0301-620x.41b1.160
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发表时间：
1959-01-01
影响因子：
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通讯作者：
CHALMERS, J
中科院分区：
文献类型：
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作者：
CHALMERS, J
将新鲜骨自体移植到大鼠的肌床中，从大约第4天开始引起活跃的新骨形成。移植物在第18天呈中空的小骨形式，中央有骨髓：其轮廓逐渐变得更加规则，并且在6个月时仍然存在。新鲜同种骨移植物在早期和晚期产生了2个独立的新骨形成阶段[长破折号]。在早期阶段，非板层编织骨出现在第4天左右，继续生长，直到第8天，随后死亡。它起源于同种移植物的成骨细胞。在4周后与少数移植物相关的晚期阶段，新骨具有板层特征，并保持紧密贴附于移植物表面。有证据表明，这种骨是由移植部位的宿主结缔组织化生引起的。同种骨移植物出现局部炎症反应。如果动物在4周前从同一供体制备了同种异体皮肤移植物，则两个阶段的同种移植物新骨形成被废除，但如果2次移植手术之间间隔4个月，则不会。冷冻干燥同种骨移植物没有产生早期的同种新骨，但在5个月后产生了一些晚期的例子。冷冻干燥的同种移植物的炎症反应比新鲜的同种移植物的炎症反应要轻。同种异体新鲜骨移植后3周的皮肤移植物在5-6天发生早期排斥反应。同种异体皮肤移植3周后，平均存活时间为12天，明显长于正常大鼠的平均存活时间10-9天。
Fresh bone autografts to a muscle bed in the rat gave rise to vigorous new bone formation from about the 4th day. The graft took the form of a hollow ossicle with central bone marrow at 18 days: it became progressively more regular in outline and was still present at 6 months. Fresh bone homo-grafts produced 2 separate phases of new bone formation[long dash]early and late. In the early phase non-lamellar woven bone appeared at about the 4th day, continued to grow until 8 days, and subsequently died. It arose from osteogenic cells of the homograft. In the late phase, which developed in relation to a few grafts after 4 weeks, the new bone was lamellar in character, and remained closely applied to the graft surface. Evidence is presented that this bone arose by metaplasia of the host connective tissues at the graft site. There was a local inflammatory response to the bone homograft. Both phases of homo-graft new bone formation were abolished if the animal was prepared by a skin homograft from the same donor 4 weeks before, but not if 4 months elapsed between the 2 grafting procedures. Freeze-dried bone homografts did not give rise to the early phase of homograft new bone but produced a few examples of the late phase after 5 months. The inflammatory response was less intense with freeze-dried homo-grafts than with fresh homografts. Skin homografts 3 weeks after fresh bone homografts from the same donor underwent an early rejection at 5-6 days. Skin homografts 3 weeks after freeze-dried bone homografts from the same donor had a mean survival time of twelve days, which was significantly longer than the mean survival time of 10-9 days in normal rats.