The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
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DOI：
10.1002/mpr.256
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发表时间：
2008-09-01
影响因子：
3.1
通讯作者：
Van Dyck, Richard
中科院分区：
文献类型：
--
作者：
Penninx, Brenda W. J. H.;Beekman, Aartjan T. F.;Van Dyck, Richard
荷兰抑郁和焦虑研究（NESDA）是一项多中心自然主义队列研究，旨在：（1）描述抑郁症和焦虑症的长期病程和后果，和（2）在流行病学方法中整合生物学和心理社会学研究范式，长期过程和后果的预测因素（之间的相互作用）。它的设计是一个八-在2981名年龄在18岁到65岁之间的参与者中进行了一年的纵向队列研究。样本包括1701人与当前（近6个月）抑郁症和/或焦虑症的诊断，907人的终身诊断或风险，因为家族史或阈下抑郁或焦虑症状，和373名健康对照。招募工作是在一般人群、一般诊所（通过三阶段筛选程序）和精神卫生组织中进行的，目的是招募反映不同背景和精神病理学发展阶段的人员。在为期四小时的基线评估期间，包括书面问卷，访谈，体检，认知计算机任务以及血液和唾液样本的收集，收集了有关关键（心理）健康结果以及人口统计学，心理社会，临床，生物学和遗传决定因素的广泛信息。详细的评估将在一年、二年、四年和八年的随访后重复进行，NESDA的发现有望为成年人抑郁和焦虑障碍的长期病程（预测因素）提供更详细的见解。除了其科学相关性外，这可能有助于更有效地预防和治疗抑郁症和焦虑症。版权所有（c）2008约翰威利父子有限公司。
The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial research paradigms within an epidemiological approach in order to examine (interaction between) predictors of the long-term course and consequences.Its design is an eight-year longitudinal cohort study among 2981 participants aged 18 through 65 years. The sample consists of 1701 persons with a current (six-month recency) diagnosis of depression and/or anxiety disorder, 907 persons with life-time diagnoses or at risk because of a family history or subthreshold depressive or anxiety symptoms, and 373 healthy controls. Recruitment took place in the general population, in general practices (through a three-stage screening procedure), and in mental health organizations in order to recruit persons reflecting various settings and developmental stages of psychopathology. During a four-hour baseline assessment including written questionnaires, interviews, a medical examination, a cognitive computer task and collection of blood and saliva samples, extensive information was gathered about key (mental) health outcomes and demographic, psychosocial, clinical, biological and genetic determinants. Detailed assessments will be repeated after one, two, four and eight years of follow-up.The findings of NESDA are expected to provide more detailed insight into (predictors of) the long-term course of depressive and anxiety disorders in adults. Besides its scientific relevance, this may contribute to more effective prevention and treatment of depressive and anxiety disorders. Copyright (c) 2008 John Wiley & Sons, Ltd.