Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome
Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome
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唐氏综合症急性白血病和短暂性骨髓增殖性疾病的细胞遗传学研究结果和临床特征
DOI：
10.1182/blood.v72.1.15.bloodjournal72115
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发表时间：
1988
期刊：
影响因子：
20.3
通讯作者：
R. Hanada
中科院分区：
文献类型：
--
作者：
Y. Hayashi;M. Eguchi;K. Sugita;S. Nakazawa;Takeyuki Sato;S. Kojima;F. Bessho;S. Konishi;T. Inaba;R. Hanada
Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's syndrome, 13 with acute leukemia (DS-AL) and 15 with transient myeloproliferative disorders (DS-TMD). Clonal chromosome abnormalities were found in the cells of all patients with DS-AL but not those with DS-TMD. The younger ages and higher hemoglobin concentrations, platelet counts, and WBC counts of DS-TMD patients provided a clinical contrast with the frankly leukemic cases. Myelodysplastic syndrome, characterized by a small percentage of leukemic blast cells, was observed in 11 of the 13 patients with DS-AL compared with none in the DS-TMD group. Electron microscopy disclosed a positive platelet peroxidase reaction in each of the 11 DS-TMD patients and in nine of the 13 DS-AL patients. Immunologic studies revealed antiplatelet- megakaryocyte antigens on the blast cells of the majority of patients in both study groups. Our findings suggest that the blast cells in cases of DS-AL and DS-TMD arise from cells of the megakaryocytic lineage or from a myeloid progenitor with the capacity for megakaryocytic differentiation. The high risk of the development of AL in patients with DS who are less than 3 years old may be related to increased megakaryocyte proliferation in this age group.
唐氏综合症急性白血病的染色体线索。
影响因子：
--
作者：
Hecht,F;Hecht,BK;Morgan,R;Sandberg,AA;Link,MP
通讯作者：
Link,MP
患有唐氏综合症的白血病：短暂性先天性骨髓增殖综合症后急性粒单核细胞白血病中 1 号和 19 号染色体之间的易位。
影响因子：
20.3
作者：
Morgan,R;Hecht,F;Cleary,ML;Sklar,J;Link,MP
通讯作者：
Link,MP